NAE1 and UBE2M

Number of citations of the paper that reports this interaction (PMID 17353931)
246

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, x-ray crystallography, pull down)

		NAE1	UBE2M
Gene Name		NEDD8 activating enzyme E1 subunit 1	ubiquitin-conjugating enzyme E2M
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ribosomal S6-glutamic Acid Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Mitotic DNA Replication Checkpoint Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Protein Neddylation Neuron Apoptotic Process	Cellular Protein Modification Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Protein Neddylation
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs		Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ALG8 APP NEDD8 SREBF2 TP53BP2 TRIP12 UBA3 UBC UBE2F UBE2M UBQLN4	24 interactors: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL3 CUL7 DCUN1D3 DCUN1D4 MARCH7 MDM2 NAE1 NEDD4 NEDD8 PARK2 PINK1 RBX1 RNF111 RNF7 TP53 UBA3 UBC
Entrez ID		8883	9040
HPRD ID		04545	04414
Ensembl ID		ENSG00000159593	ENSG00000130725
Uniprot IDs		A6NCK0 A8MU28 Q13564	P61081
PDB IDs		1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN	1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Regulation Of ERBB Signaling Pathway Protein Metabolic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Ubiquitination Signal Transduction By P53 Class Mediator Cholesterol Metabolic Process Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting In Absence Of Injury Negative Regulation Of Histone H2A K63-linked Ubiquitination Endomitotic Cell Cycle Modification-dependent Protein Catabolic Process Sterol Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Histone Ubiquitination Negative Regulation Of Protein K63-linked Ubiquitination Notch Signaling Pathway Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cholesterol Efflux Response To Growth Factor Protein Catabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein K63-linked Ubiquitination Regulation Of Proteolysis Axon Choice Point Recognition Negative Regulation Of Double-strand Break Repair Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of DNA Repair Intracellular Receptor Signaling Pathway Proteolysis Regulation Of Protein Ubiquitination Neuron Remodeling Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Neddylation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Protein Monoubiquitination Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hypoxia Regulation Of Mitochondrion Degradation Cellular Response To Decreased Oxygen Levels Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cellular Response To Oxygen Levels Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Catabolic Process Notch Signaling Pathway Regulation Of Cell Cycle Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Catabolic Process Viral Process Protein Polyubiquitination Negative Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Apoptotic Process Cellular Response To Toxic Substance Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process Signaling Mitotic Cell Cycle Process Response To Oxidative Stress
Tagcloud ?		addressed app bp1 bring clonogenic constructs conversely elusive emerged hnscc hnsccs hpv16 invovled ionizing modality naturally nedd8 neddylation oropharyngeal radioresistant radiosensitive radiosensitivity radiotherapy rays scc90 sirnas sq20b subpopulation upci	acts affects balance brca1 breaks choice controller controlling ctip cytotoxic deneddylation great homologous indeed neddylation nhej recombination repair repaired resection respond rnf111 ssdna strand subpathways tight toward uncover way
Tagcloud (Difference) ?		addressed app bp1 bring clonogenic constructs conversely elusive emerged hnscc hnsccs hpv16 invovled ionizing modality naturally nedd8 oropharyngeal radioresistant radiosensitive radiosensitivity radiotherapy rays scc90 sirnas sq20b subpopulation upci	acts affects balance brca1 breaks choice controller controlling ctip cytotoxic deneddylation great homologous indeed nhej recombination repair repaired resection respond rnf111 ssdna strand subpathways tight toward uncover way
Tagcloud (Intersection) ?		neddylation