NAE1 and ALG8

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NAE1	ALG8
Gene Name		NEDD8 activating enzyme E1 subunit 1	ALG8, alpha-1,3-glucosyltransferase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding NEDD8 Activating Enzyme Activity Ubiquitin Protein Ligase Binding Protein Heterodimerization Activity	Alpha-1,3-mannosyltransferase Activity Dolichyl Pyrophosphate Man9GlcNAc2 Alpha-1,3-glucosyltransferase Activity
	Biological Process	Signal Transduction Mitotic DNA Replication Checkpoint Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Protein Neddylation Neuron Apoptotic Process	Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Mannosylation
Pathways			Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Defective ALG11 causes ALG11-CDG (CDG-1p) Diseases associated with N-glycosylation of proteins
Drugs		Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ALG8 APP NEDD8 SREBF2 TP53BP2 TRIP12 UBA3 UBC UBE2F UBE2M UBQLN4	2 interactors: NAE1 RPS6KA5
Entrez ID		8883	79053
HPRD ID		04545	10480
Ensembl ID		ENSG00000159593	ENSG00000159063
Uniprot IDs		A6NCK0 A8MU28 Q13564	Q9BVK2
PDB IDs		1R4M 1R4N 1TT5 1YOV 2NVU 3DBH 3DBL 3DBR 3GZN
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle Regulation Of ERBB Signaling Pathway Protein Metabolic Process Oligosaccharide-lipid Intermediate Biosynthetic Process Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Ubiquitination Signal Transduction By P53 Class Mediator Cholesterol Metabolic Process Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting In Absence Of Injury Negative Regulation Of Histone H2A K63-linked Ubiquitination Endomitotic Cell Cycle Modification-dependent Protein Catabolic Process Sterol Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Histone Ubiquitination Negative Regulation Of Protein K63-linked Ubiquitination Notch Signaling Pathway Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Cholesterol Efflux Response To Growth Factor Protein Catabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Protein K63-linked Ubiquitination Regulation Of Proteolysis Axon Choice Point Recognition Negative Regulation Of Double-strand Break Repair Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of DNA Repair Intracellular Receptor Signaling Pathway Proteolysis Regulation Of Protein Ubiquitination Neuron Remodeling Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process	Histone H2A-S1 Phosphorylation Histone H3-S10 Phosphorylation Mitotic DNA Replication Checkpoint Positive Regulation Of Histone Phosphorylation Histone H3-S28 Phosphorylation Protein Neddylation DNA Replication Checkpoint Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Interleukin-1-mediated Signaling Pathway Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Histone Acetylation Histone-serine Phosphorylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Histone Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Histone Acetylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Cellular Response To Interleukin-1 Neuron Apoptotic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Neuron Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Histone Modification Toll-like Receptor 4 Signaling Pathway Response To Interleukin-1 Mitotic DNA Integrity Checkpoint Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Peptidyl-serine Phosphorylation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Histone Modification Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Negative Regulation Of Mitotic Cell Cycle Phase Transition
Tagcloud ?		addressed app bp1 bring clonogenic constructs conversely elusive emerged hnscc hnsccs hpv16 invovled ionizing modality naturally nedd8 neddylation oropharyngeal radioresistant radiosensitive radiosensitivity radiotherapy rays scc90 sirnas sq20b subpopulation upci
Tagcloud (Difference) ?		addressed app bp1 bring clonogenic constructs conversely elusive emerged hnscc hnsccs hpv16 invovled ionizing modality naturally nedd8 neddylation oropharyngeal radioresistant radiosensitive radiosensitivity radiotherapy rays scc90 sirnas sq20b subpopulation upci
Tagcloud (Intersection) ?