PPP2R5B

Description		protein phosphatase 2 regulatory subunit B'beta
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	Signal Transduction Positive Regulation Of Neuron Projection Development Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Cycle Negative Regulation Of G0 To G1 Transition Cellular Response To Growth Factor Stimulus
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion XBP1(S) activates chaperone genes Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Serum uric acid levels ( 32514006)
Novel Interacting Genes		1 novel interacting genes: MARK2
Interacting Genes		8 interacting genes: AXIN1 BUB1B CHEK2 IER3 MAPK1 PPP2CA PPP2R1A SGO1
Entrez ID		5526
HPRD ID		09038
Ensembl ID		ENSG00000068971
Uniprot IDs		Q15173
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome, Centromeric Region Sister Chromatid Cohesion Meiotic Sister Chromatid Cohesion, Centromeric Intracellular Signal Transduction Lateral Plasma Membrane Microtubule Cytoskeleton Regulation Of Organelle Organization Meiotic Sister Chromatid Cohesion Regulation Of Cell Cycle Process Protein Serine Kinase Activity Organelle Organization Cell Death Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition Programmed Cell Death Microtubule Cytoskeleton Organization INTAC Complex RNA Polymerase II Transcription Initiation Surveillance FAR/SIN/STRIPAK Complex Negative Regulation Of Glycolytic Process Protein Phosphatase Type 2A Complex Negative Regulation Of Hippo Signaling Negative Regulation Of ATP Metabolic Process Regulation Of Mitotic Cell Cycle Protein Kinase Activity Regulation Of Cell Cycle Signal Transduction Catabolic Process Negative Regulation Of Mitotic Cell Cycle T Cell Homeostasis Nuclear RNA Surveillance Kinase Activity Negative Regulation Of Cell Cycle Phase Transition RNA Surveillance Tau Protein Binding Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Chromosome Phosphate-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Signal Transduction Regulation Of Glycolytic Process DNA-templated Transcription Elongation Mesoderm Development Cytoskeleton Regulation Of Cellular Component Organization Microtubule-based Process Regulation Of Carbohydrate Catabolic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity
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