PPP2R5B and SGO1

Number of citations of the paper that reports this interaction (PubMedID 16541024)
0

Data Source:
HPRD (in vivo)

		PPP2R5B	SGO1
Description		protein phosphatase 2 regulatory subunit B'beta	shugoshin 1
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Speck
	Molecular Function	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity	Protein Binding Kinase Binding
	Biological Process	Signal Transduction Positive Regulation Of Neuron Projection Development Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Cycle Negative Regulation Of G0 To G1 Transition Cellular Response To Growth Factor Stimulus	Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centriole-centriole Cohesion Meiotic Chromosome Segregation Cell Division Mitotic Sister Chromatid Cohesion, Centromeric
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion XBP1(S) activates chaperone genes Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Serum uric acid levels ( 32514006)
Interacting Genes		8 interacting genes: AXIN1 BUB1B CHEK2 IER3 MAPK1 PPP2CA PPP2R1A SGO1	21 interacting genes: CDCA8 LRRC59 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC PTPA RPL10A RPL28 RPL7 RPL7A RPLP1 SET XRCC5 XRCC6
Entrez ID		5526	151648
HPRD ID		09038	12377
Ensembl ID		ENSG00000068971	ENSG00000129810
Uniprot IDs		Q15173	B5BUA4 Q5FBB7
PDB IDs			3FGA 3Q6S 4A0I 7ZJS
Enriched GO Terms of Interacting Partners?		Chromosome, Centromeric Region Sister Chromatid Cohesion Meiotic Sister Chromatid Cohesion, Centromeric Intracellular Signal Transduction Lateral Plasma Membrane Microtubule Cytoskeleton Regulation Of Organelle Organization Meiotic Sister Chromatid Cohesion Regulation Of Cell Cycle Process Protein Serine Kinase Activity Organelle Organization Cell Death Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition Programmed Cell Death Microtubule Cytoskeleton Organization INTAC Complex RNA Polymerase II Transcription Initiation Surveillance FAR/SIN/STRIPAK Complex Negative Regulation Of Glycolytic Process Protein Phosphatase Type 2A Complex Negative Regulation Of Hippo Signaling Negative Regulation Of ATP Metabolic Process Regulation Of Mitotic Cell Cycle Protein Kinase Activity Regulation Of Cell Cycle Signal Transduction Catabolic Process Negative Regulation Of Mitotic Cell Cycle T Cell Homeostasis Nuclear RNA Surveillance Kinase Activity Negative Regulation Of Cell Cycle Phase Transition RNA Surveillance Tau Protein Binding Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Chromosome Phosphate-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Signal Transduction Regulation Of Glycolytic Process DNA-templated Transcription Elongation Mesoderm Development Cytoskeleton Regulation Of Cellular Component Organization Microtubule-based Process Regulation Of Carbohydrate Catabolic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity	Protein Phosphatase Type 2A Complex Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity Meiotic Sister Chromatid Cohesion Chromosome Organization Cytosolic Large Ribosomal Subunit DNA-dependent Protein Kinase Complex Chromosome, Centromeric Region DNA-dependent Protein Kinase-DNA Ligase 4 Complex Nonhomologous End Joining Complex Cytosolic Ribosome Sister Chromatid Cohesion Cytosol Cytoplasmic Translation Nucleus Structural Constituent Of Ribosome FAR/SIN/STRIPAK Complex Chromosome DNA End Binding Ku70:Ku80 Complex Ribosome Small-subunit Processome Assembly Cytoplasm Ribonucleoprotein Complex Meiotic Sister Chromatid Cohesion, Centromeric Protein-DNA Complex 5'-deoxyribose-5-phosphate Lyase Activity Response To Gamma Radiation Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding Macromolecule Biosynthetic Process Spindle Organization Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ribonucleoprotein Complex Biogenesis Translation U3 SnoRNA Binding Protein Serine/threonine Phosphatase Activity INTAC Complex Spindle Assembly Response To Lead Ion Telomere Maintenance RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Ribosome Biogenesis Hyperosmotic Response RNA Binding Maturation Of LSU-rRNA Telomeric DNA Binding Cellular Response To Gamma Radiation
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