FKBP7 and NPFFR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FKBP7	NPFFR2
Description		FKBP prolyl isomerase 7	neuropeptide FF receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Plasma Membrane Actin Cytoskeleton Membrane
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Calcium Ion Binding Protein Binding FK506 Binding Isomerase Activity Metal Ion Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Opioid Receptor Binding
	Biological Process		Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Detection Of Abiotic Stimulus Cellular Response To Hormone Stimulus Regulation Of MAPK Cascade
Pathways			Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Atrial fibrillation ( 30061737) Blood protein levels ( 30072576) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)
Interacting Genes		107 interacting genes: ABHD16A ADGRE2 ADIPOQ AP1M1 APOD ASPH BET1 BMP10 BRICD5 C3orf52 CD81 CDIPT CDS2 CERCAM CFTR CIAO2A CLCA4 CLDN19 CNIH1 CTSA CXCL16 CYB561D2 CYB5B DIABLO ERMP1 FAM3C FARS2 GET3 H4C7 HHATL HMOX1 HSBP1L1 HTATIP2 IER3 IFITM3 IGFBP5 IRF2 JOSD2 LAT LNPEP MAN2B2 MIEF2 MRM1 NFU1 NKG7 NPFFR2 OCIAD1 OXNAD1 PBX3 PCYT1A PEX16 PEX19 PLLP PLP1 PLP2 PLPP6 PPIF PRMT6 PTCD1 PTPN9 RBFA RPRM RUSF1 SELENOK SERP1 SGTA SLC30A3 SLC38A7 SLC7A14 SNX1 SNX12 STATH STX7 STX8 SUCLA2 TARS2 TCP11X2 TECR TF THAP4 THSD7B TMEM108 TMEM120B TMEM147 TMEM14A TMEM229B TMEM239 TMEM54 TMEM86A TMEM86B TMEM97 TRAM1L1 TSPAN2 TSPO2 TTPA TXNDC12 UBIAD1 UBQLN4 UNC93B1 UPK1B UPK2 VSTM4 WFDC2 WIPI2 YIPF4 YIPF6 ZFPL1	6 interacting genes: FKBP7 HCRT NPFF NPY TMEM218 TRARG1
Entrez ID		51661	10886
HPRD ID		08451	16244
Ensembl ID		ENSG00000079150	ENSG00000056291
Uniprot IDs		B4DRE2 Q9Y680	A0A804CC06 A0PJM9 Q9Y5X5
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein Binding Chloride Channel Inhibitor Activity Regulation Of Cellular Localization Cellular Localization Protein Insertion Into ER Membrane Transferrin Receptor Binding Alkenylglycerophosphocholine Hydrolase Activity Lysosome Peroxisome Membrane Biogenesis Intraciliary Transport Particle B Binding Cholesterol Binding Establishment Of Localization In Cell	Neuropeptide Hormone Activity Neuropeptide Signaling Pathway Regulation Of Response To Food Neuronal Dense Core Vesicle Regulation Of Appetite Regulation Of Response To Nutrient Levels Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Excitatory Postsynaptic Potential Type 1 Orexin Receptor Binding Regulation Of Neurotransmitter Secretion Feeding Behavior Type 2 Orexin Receptor Binding G Protein-coupled Receptor Binding Short-day Photoperiodism Regulation Of Postsynaptic Membrane Potential Regulation Of Secretion By Cell Regulation Of Nerve Growth Factor Production Neuropeptide Activity Somatostatin Secretion Cell-cell Signaling Cell Communication Regulation Of Secretion Signaling Neuropeptide Y Receptor Binding Perikaryon Vasopressin Secretion Positive Regulation Of Cytosolic Calcium Ion Concentration Perinuclear Region Of Cytoplasm Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Regulation Of Blood Pressure G Protein-coupled Receptor Signaling Pathway Neuronal Dense Core Vesicle Lumen Negative Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Dopamine Metabolic Process Glucose Import In Response To Insulin Stimulus Positive Regulation Of Transmission Of Nerve Impulse Sleep Postsynapse Regulation Of Eating Behavior Synaptic Signaling Via Neuropeptide Monocyte Activation Adult Feeding Behavior FK506 Binding Antifungal Humoral Response Intestinal Epithelial Cell Differentiation
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