TSC22D1 and LPAR6

		TSC22D1	LPAR6
Description		TSC22 domain family member 1	lysophosphatidic acid receptor 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding Identical Protein Binding	G Protein-coupled Receptor Activity Protein Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Negative Regulation Of Hematopoietic Stem Cell Proliferation	Blastocyst Hatching Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways			G alpha (q) signalling events P2Y receptors
Drugs			Promethazine
Diseases			Localized autosomal recessive hypotrichosis Woolly hair, including: Autosomal-dominant woolly hair (ADWH); Autosomal-recessive woolly hair (ARWH); Autosomal-recessive woolly hair with or without hypotrichosis
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Body mass index ( 25760438) Refractive error ( 32231278) Rosacea symptom severity ( 29771307)	Lymphocyte count ( 32888494)
Interacting Genes		51 interacting genes: A2M APLP1 ASAH1 CACNA1A CARHSP1 CCDC90B CFTR CHD3 CORO2B CRMP1 DDAH2 DNMT3B EED ERG28 FAF1 FAM20C FBN3 GNB2 GNB5 GORASP2 HMGXB4 KMT2B KMT2C LRIF1 MAP3K12 MCM3AP NCOA5 NTAQ1 OTUB1 PDHB PRKCI PTN QARS1 RGS1 RPL5 SETDB1 SP110 SPACA9 SPRED1 TAF5L TGFBR1 TLE1 TP53 TSC22D4 UBE2D1 UNC119 VIM WDR73 WIZ WNK1 ZC3HC1	4 interacting genes: EMP1 RPRM SEC22A SMIM3
Entrez ID		8848	10161
HPRD ID		07414	16465
Ensembl ID		ENSG00000102804	ENSG00000139679
Uniprot IDs		A8K3Y6 Q15714	B3KVQ5 P43657
PDB IDs			9ITB 9ITE
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Signal Transduction Regulation Of Primary Metabolic Process Nucleus Nucleoplasm Negative Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Negative Regulation Of Signaling Histone H3K4 Monomethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
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