LPAR6 and SMIM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LPAR6	SMIM3
Description		lysophosphatidic acid receptor 6	small integral membrane protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Lysophosphatidic Acid Receptor Activity	Protein Binding Identical Protein Binding
	Biological Process	Blastocyst Hatching Signal Transduction G Protein-coupled Receptor Signaling Pathway
Pathways		G alpha (q) signalling events P2Y receptors
Drugs		Promethazine
Diseases		Localized autosomal recessive hypotrichosis Woolly hair, including: Autosomal-dominant woolly hair (ADWH); Autosomal-recessive woolly hair (ARWH); Autosomal-recessive woolly hair with or without hypotrichosis
GWAS		Lymphocyte count ( 32888494)	Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 28067908)
Interacting Genes		4 interacting genes: EMP1 RPRM SEC22A SMIM3	52 interacting genes: ASGR2 ATP1B4 ATP6V0C BNIP3 BSCL2 BTNL9 CD53 CD79A CD82 CLDN11 CLDN5 CLDN8 CLEC17A CLEC7A CNIH1 CNIH3 EBP EMP1 EMP3 ERGIC3 FNDC9 GIMAP5 GPR42 IFNGR2 KIR3DL3 LPAR6 LSMEM2 LZTS2 MAL MS4A3 PDCD1LG2 PLP1 PMP22 PNMA1 PSCA RPRM SEC22A SFTPC SGCB SGCZ SLC22A1 SLC38A1 SMCO4 SPACA1 STX1A TEX264 TM4SF18 TMEM182 TMEM218 TMEM31 TRIM14 ZFPL1
Entrez ID		10161	85027
HPRD ID		16465	12212
Ensembl ID		ENSG00000139679	ENSG00000256235
Uniprot IDs		B3KVQ5 P43657	Q9BZL3
PDB IDs		9ITB 9ITE
Enriched GO Terms of Interacting Partners?			Membrane Plasma Membrane Bleb Assembly Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Endoplasmic Reticulum Membrane Sarcoglycan Complex Fucose Binding Myelination Pattern Recognition Receptor Activity Bicellular Tight Junction Assembly Protein Binding Structural Constituent Of Myelin Sheath Schmidt-Lanterman Incisure Tight Junction Assembly Bicellular Tight Junction Central Nervous System Myelination Tight Junction Organization
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