DCAF5 and CUL4B

Number of citations of the paper that reports this interaction (PubMedID 34026424)
83

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		DCAF5	CUL4B
Description		DDB1 and CUL4 associated factor 5	cullin 4B
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Fatty Acid Biosynthetic Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Gene Expression Proteasomal Protein Catabolic Process Protein Ubiquitination Cellular Response To UV Ribosome Biogenesis Positive Regulation Of Protein Catabolic Process Astrocyte Differentiation UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Neddylation	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases			Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Intelligence (MTAG) ( 29326435) Mean platelet volume ( 27863252 32888494) Neuroticism ( 29255261) Platelet count ( 32888494) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: CUL4B DNMT1 DYRK1A	45 interacting genes: AHR APP AR BRWD1 BRWD3 CAND1 CDK1 COMMD1 COP1 COPS5 CSNK1A1 DCAF10 DCAF11 DCAF12 DCAF16 DCAF17 DCAF5 DCUN1D4 DDA1 DDB1 DDB2 DNMT3B ESR1 HDAC2 HDAC3 HUWE1 KPNA2 KPNA4 KPNB1 MTA2 NEDD8 PAFAH1B1 PLK1 PRDX3 PTEN PWP1 RBX1 SALL2 SIN3A SIRT1 ST7 TBL3 UBC UBE2D3 ZMAT4
Entrez ID		8816	8450
HPRD ID		16032	02251
Ensembl ID		ENSG00000139990	ENSG00000158290
Uniprot IDs		Q8TBB7 Q96JK2	K4DI93 Q13620
PDB IDs		3I89 8TL6	2DO7 4A0C 4A0L 4A64 8EI1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process DNA-methyltransferase Activity Chromosomal DNA Methylation Maintenance Following DNA Replication Response To Bisphenol A Regulation Of Phenotypic Switching Germ Cell Nucleus Cellular Response To Bisphenol A DNA (cytosine-5-)-methyltransferase Activity Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Histone H3T45 Kinase Activity Cul4B-RING E3 Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Regulation Of Heterochromatin Formation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Neurofilament UV-damage Excision Repair Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Female Germ Cell Nucleus Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Repair Cul4A-RING E3 Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Smooth Muscle Cell Differentiation Tau-protein Kinase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Inclusion Body Assembly Chromatin Remodeling Regulation Of Chromatin Organization LncRNA Binding Methyl-CpG Binding Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of RNA Splicing Cul4-RING E3 Ubiquitin Ligase Complex Replication Fork Pericentric Heterochromatin DNA Metabolic Process Astrocyte Differentiation Epigenetic Programming Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process DNA Damage Response Regulation Of Smooth Muscle Cell Apoptotic Process DNA Methylation-dependent Constitutive Heterochromatin Formation	Cul4-RING E3 Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein Ubiquitination Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Protein Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Positive Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Enzyme Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Histone Deacetylase Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Response To Hydrogen Peroxide Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Cul4B-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Response To Oxidative Stress Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex
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