DCAF5

Description		DDB1 and CUL4 associated factor 5
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding
	Biological Process	Protein Ubiquitination Negative Regulation Of Fatty Acid Biosynthetic Process
Pathways		Neddylation
Drugs
Diseases
GWAS		Intelligence (MTAG) ( 29326435) Mean platelet volume ( 27863252 32888494) Neuroticism ( 29255261) Platelet count ( 32888494) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: CUL4B DNMT1 DYRK1A
Entrez ID		8816
HPRD ID		16032
Ensembl ID		ENSG00000139990
Uniprot IDs		Q8TBB7 Q96JK2
PDB IDs		3I89 8TL6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process DNA-methyltransferase Activity Chromosomal DNA Methylation Maintenance Following DNA Replication Response To Bisphenol A Regulation Of Phenotypic Switching Germ Cell Nucleus Cellular Response To Bisphenol A DNA (cytosine-5-)-methyltransferase Activity Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Histone H3T45 Kinase Activity Cul4B-RING E3 Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Regulation Of Heterochromatin Formation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Neurofilament UV-damage Excision Repair Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Female Germ Cell Nucleus Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Negative Regulation Of Microtubule Polymerization Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Repair Cul4A-RING E3 Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Smooth Muscle Cell Differentiation Tau-protein Kinase Activity Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Inclusion Body Assembly Chromatin Remodeling Regulation Of Chromatin Organization LncRNA Binding Methyl-CpG Binding Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of RNA Splicing Cul4-RING E3 Ubiquitin Ligase Complex Replication Fork Pericentric Heterochromatin DNA Metabolic Process Astrocyte Differentiation Epigenetic Programming Of Gene Expression Positive Regulation Of Macromolecule Metabolic Process DNA Damage Response Regulation Of Smooth Muscle Cell Apoptotic Process DNA Methylation-dependent Constitutive Heterochromatin Formation
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