IL18R1 and IL1RAP

Number of citations of the paper that reports this interaction (PMID 8626725)
26

Data Source:
HPRD (in vitro, in vivo)

		IL18R1	IL1RAP
Gene Name		interleukin 18 receptor 1	interleukin 1 receptor accessory protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Receptor Activity Interleukin-1 Receptor Activity Protein Binding Interleukin-18 Receptor Activity	Signal Transducer Activity Interleukin-1 Receptor Activity
	Biological Process	Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Interferon-gamma Production Interleukin-18-mediated Signaling Pathway Positive Regulation Of NF-kappaB Import Into Nucleus T-helper 1 Cell Differentiation	Protein Complex Assembly Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Interleukin-2 Biosynthetic Process Innate Immune Response
Pathways
Drugs
Diseases
GWAS		Asthma ( 23028483 20860503 22561531) Atopic dermatitis ( 23042114) Celiac disease ( 20190752 18311140) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233)	Lung cancer ( 18385676) Waist circumference ( 20966902)
Protein-Protein Interactions		4 interactors: CD48 IL18 IL1RAP IL37	19 interactors: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCH8 MC4R MYD88 PIK3R1 PRKCI PRPF40A RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		8809	3556
HPRD ID		05138	04021
Ensembl ID		ENSG00000115604	ENSG00000196083
Uniprot IDs		B7ZKV7 Q13478	A8K6K4 Q9NPH3
PDB IDs			3O4O 4DEP
Enriched GO Terms of Interacting Partners?		Interleukin-2 Biosynthetic Process Interleukin-2 Production Cytokine Biosynthetic Process Cytokine Metabolic Process Defense Response Inflammatory Response Immune System Process Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Chemokine Biosynthetic Process Interleukin-13 Biosynthetic Process Cytokine Production Interferon-gamma Biosynthetic Process Response To Stress Positive Regulation Of NK T Cell Proliferation Immune Response Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Chemokine Metabolic Process Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Chemokine Production Type 2 Immune Response Positive Regulation Of Interleukin-17 Production Cellular Response To Organic Substance Cytokine-mediated Signaling Pathway Positive Regulation Of Alpha-beta T Cell Proliferation Sleep Interferon-gamma Production Cellular Response To Cytokine Stimulus Positive Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Myoblast Differentiation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Natural Killer Cell Activation Response To Organic Substance T-helper 1 Type Immune Response Positive Regulation Of Tissue Remodeling Response To Cytokine Regulation Of Activated T Cell Proliferation Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Regulation Of NF-kappaB Import Into Nucleus Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Cell Surface Receptor Signaling Pathway Positive Regulation Of Interferon-gamma Production Natural Killer Cell Activation Regulation Of Tissue Remodeling Positive Regulation Of T Cell Proliferation Response To Stimulus Regulation Of Interferon-gamma Production Regulation Of Transcription Factor Import Into Nucleus	Response To Cytokine Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Cytokine Stimulus Immune System Process Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Inflammatory Response Cell Surface Receptor Signaling Pathway Regulation Of Cytokine Production Positive Regulation Of Signal Transduction Signal Transduction Positive Regulation Of Cytokine Production Defense Response Response To Interleukin-1 Signaling Cell Communication Temperature Homeostasis Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Positive Regulation Of NF-kappaB Transcription Factor Activity Fever Generation Acute-phase Response Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription Factor Import Into Nucleus Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Chemokine Production Intracellular Signal Transduction Cellular Response To Stimulus Response To Growth Factor Positive Regulation Of Protein Transport Negative Regulation Of Cell Death Cellular Response To Lipopolysaccharide Positive Regulation Of Immune Response Positive Regulation Of Intracellular Protein Transport Cellular Response To Molecule Of Bacterial Origin Regulation Of Protein Import Into Nucleus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Establishment Of Protein Localization Regulation Of Chemokine Production Heat Generation Response To Stimulus
Tagcloud ?		affymetrix ancestry beyond ccr6 consortium crohn focusing genuine genuinely gwa harboring hits homologs humanhap550 il12 il12b il23 illumina reach replicated snp true trust tyk2 uncovered unleashing wellcome wtccc	36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rl2 il36g il36gamma il36r il8 ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding
Tagcloud (Difference) ?		affymetrix ancestry beyond ccr6 consortium crohn focusing genuine genuinely gwa harboring hits homologs humanhap550 il12 il12b il23 illumina reach replicated snp true trust tyk2 uncovered unleashing wellcome wtccc	36gamma 36r alarmin atopic augments camp cathelicidin ccl20 cxcl1 cxcl10 dermatitis dermatoses exacerbations il1rl2 il36g il36gamma il36r il8 ip10 keratinocytes lesional ll37 mip3a nonlesional occasional pertussis psoriasis rosacea wounding
Tagcloud (Intersection) ?