IL18R1 and IL1RAP

Number of citations: 0 (PubMedID 8626725)
Data Source: HPRD (in vitro, in vivo)

		IL18R1	IL1RAP
Name		interleukin 18 receptor 1	interleukin 1 receptor accessory protein
Structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Interleukin-18 Receptor Complex	Extracellular Region Plasma Membrane Cell Surface Membrane Synapse Glutamatergic Synapse
	Molecular Function	Interleukin-1 Receptor Activity Protein Binding Hydrolase Activity Signaling Receptor Activity Interleukin-18 Binding Interleukin-18 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Coreceptor Activity Hydrolase Activity Signaling Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Adaptive Immune Response Inflammatory Response Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Type II Interferon Production Interleukin-18-mediated Signaling Pathway T-helper 1 Cell Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Cytokine Production	Immune System Process Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Innate Immune Response Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways		Interleukin-37 signaling Interleukin-18 signaling	None
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406 ) Allergic rhinitis ( 31361310 ) Allergic sensitization ( 23817571 ) Asthma ( 29273806 31959851 22561531 31619474 31361310 20860503 30929738 26620591 23028483 ) Asthma (adult onset) ( 31036433 30929738 ) Asthma (childhood onset) ( 29273806 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 26482879 23042114 ) Atypical femoral fracture in phosphonate treatment ( 31006051 ) Bisphosphonate-associated atypical femoral fracture ( 31006051 ) Blood protein levels ( 30072576 ) Celiac disease ( 20190752 18311140 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 21102463 28067908 ) Delirium ( 29631748 ) Eczema ( 31361310 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Inflammatory bowel disease ( 28067908 23128233 ) Leprosy ( 25642632 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Nasal polyps ( 30643255 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Pediatric autoimmune diseases ( 26301688 ) Polymyositis ( 26362759 ) Primary biliary cholangitis ( 26394269 ) Sum eosinophil basophil counts ( 27863252 )	Blood protein levels ( 30072576 ) Longitudinal change in brain amyloid plaque burden ( 26268530 ) Lung cancer ( 18385676 ) Waist circumference ( 20966902 )
Novel Interactors		2 novel interactors: AFF3 AKAP8L	2 novel interactors: AP2M1 FXR1
Interacting Genes		4 interacting genes: CD48 IL18 IL1RAP IL37	20 interacting genes: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		8809	3556
HPRD ID		05138	04021
Ensembl ID		ENSG00000115604	ENSG00000196083
Uniprot IDs		B7ZKV7 Q13478	A8K6K4 Q9NPH3
PDB IDs		3WO3 3WO4 4R6U	3O4O 4DEP 7FCC
GO Terms Enriched among Interactors		Positive Regulation Of Interleukin-13 Production Natural Killer Cell Activation Immune Response Cytokine-mediated Signaling Pathway Interleukin-18 Receptor Binding Defense Response Inflammatory Response Interleukin-33 Receptor Activity Receptor Ligand Activity Extracellular Region Immune System Process Regulation Of Cytokine Production Trans-synaptic Signaling By Trans-synaptic Complex Interleukin-1 Receptor Activity Interleukin-33-mediated Signaling Pathway Regulation Of Interleukin-6 Production Cytokine Activity Positive Regulation Of NK T Cell Proliferation Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of T-helper 2 Cell Differentiation Cellular Response To Lipopolysaccharide Sleep Positive Regulation Of T-helper 1 Cell Cytokine Production Super Elongation Complex DEAD/H-box RNA Helicase Binding Positive Regulation Of NK T Cell Activation T-helper 1 Type Immune Response Type 2 Immune Response Regulation Of MRNA Export From Nucleus Positive Regulation Of Interleukin-5 Production Positive Regulation Of Natural Killer Cell Proliferation Interleukin-1 Receptor Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Regulation Of Postsynaptic Density Assembly Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Interleukin-18-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Natural Killer Cell Proliferation Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Membrane Disassembly Nuclear Membrane Disassembly Lamin Binding Lymphocyte Activation Interleukin-1-mediated Signaling Pathway Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Positive Regulation Of Interleukin-4 Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Interleukin-5 Production	Regulation Of Cytokine Production Cytokine-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Multicellular Organismal Process Regulation Of Canonical NF-kappaB Signal Transduction Immune Response Positive Regulation Of Cytokine Production Inflammatory Response Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Interleukin-1 Receptor Activity Immune System Process Regulation Of Tumor Necrosis Factor Production Regulation Of Immune System Process Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Immune System Process Defense Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Interleukin-1 Receptor Binding Regulation Of Defense Response Positive Regulation Of Cellular Component Organization Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-6 Production Positive Regulation Of T-helper 1 Type Immune Response Response To Lipopolysaccharide Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cytokine Production Signal Transduction Regulation Of Cytokine Production Involved In Inflammatory Response Response To Cytokine Cellular Response To Molecule Of Bacterial Origin Glutamatergic Synapse Positive Regulation Of Cytokine Production Involved In Immune Response Response To Peptide Fever Generation Positive Regulation Of Transport Positive Regulation Of Interleukin-6 Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of Multicellular Organismal Process