IL18R1 and AFF3

Data Source: HiPPIP (Novel)

		IL18R1	AFF3
Name		interleukin 18 receptor 1	ALF transcription elongation factor 3
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Interleukin-18 Receptor Complex	Nucleus Nucleoplasm Cytosol Nuclear Body Super Elongation Complex
	Molecular Function	Interleukin-1 Receptor Activity Protein Binding Hydrolase Activity Signaling Receptor Activity Interleukin-18 Binding Interleukin-18 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating	DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity
	Biological Process	Adaptive Immune Response Inflammatory Response Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Type II Interferon Production Interleukin-18-mediated Signaling Pathway T-helper 1 Cell Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Cytokine Production	Regulation Of DNA-templated Transcription Regulation Of Gene Expression Response To Tumor Necrosis Factor Embryonic Hindlimb Morphogenesis
Pathways		Interleukin-37 signaling Interleukin-18 signaling	None
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406 ) Allergic rhinitis ( 31361310 ) Allergic sensitization ( 23817571 ) Asthma ( 29273806 31959851 22561531 31619474 31361310 20860503 30929738 26620591 23028483 ) Asthma (adult onset) ( 31036433 30929738 ) Asthma (childhood onset) ( 29273806 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 26482879 23042114 ) Atypical femoral fracture in phosphonate treatment ( 31006051 ) Bisphosphonate-associated atypical femoral fracture ( 31006051 ) Blood protein levels ( 30072576 ) Celiac disease ( 20190752 18311140 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 21102463 28067908 ) Delirium ( 29631748 ) Eczema ( 31361310 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Inflammatory bowel disease ( 28067908 23128233 ) Leprosy ( 25642632 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Nasal polyps ( 30643255 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Pediatric autoimmune diseases ( 26301688 ) Polymyositis ( 26362759 ) Primary biliary cholangitis ( 26394269 ) Sum eosinophil basophil counts ( 27863252 )	A body shape index ( 34021172 ) Adult body size ( 32376654 ) Age at first birth ( 27798627 ) Albumin-globulin ratio ( 29403010 ) Apolipoprotein A1 levels ( 32203549 ) Arthritis (juvenile idiopathic) ( 33106285 ) Asthma ( 34103634 ) Autoimmune traits (pleiotropy) ( 30572963 ) Cannabis dependence symptom count ( 27028160 ) Celiac disease ( 30572963 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Cognitive ability ( 29186694 ) Cognitive ability (MTAG) ( 29186694 ) Extremely high intelligence ( 29520040 ) Gastroesophageal reflux disease ( 31527586 34187846 ) General cognitive ability ( 29844566 ) Hand grip strength ( 29691431 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 31217584 ) Hip circumference adjusted for BMI ( 34021172 ) Household income ( 27818178 ) Household income (MTAG) ( 31844048 ) IgG levels ( 28628107 ) Immature fraction of reticulocytes ( 32888494 ) Intelligence ( 28530673 ) Intelligence (MTAG) ( 29326435 ) Intraocular pressure ( 29617998 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Metabolite levels ( 23823483 ) Multisite chronic pain ( 33830993 ) Non-albumin protein levels ( 29403010 ) Number of children ever born ( 27798627 ) Plateletcrit ( 27863252 32888494 ) Red blood cell count ( 27863252 ) Refractive astigmatism ( 30306274 ) Regular attendance at a religious group ( 29970889 ) Rheumatoid arthritis ( 24390342 30572963 24782177 23143596 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Serum total protein levels ( 29403010 ) Triglyceride levels ( 34074324 ) Type 1 diabetes ( 25751624 34127860 17554260 ) Type 1 diabetes nephropathy ( 23028342 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Novel Interactors		2 novel interactors: AFF3 AKAP8L	5 novel interactors: DPP8 GPR137B IL18R1 IL18RAP ST6GAL2
Interacting Genes		4 interacting genes: CD48 IL18 IL1RAP IL37	None recorded
Entrez ID		8809	3899
HPRD ID		05138	03272
Ensembl ID		ENSG00000115604	ENSG00000144218
Uniprot IDs		B7ZKV7 Q13478	P51826 Q8NAP7
PDB IDs		3WO3 3WO4 4R6U	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Interleukin-13 Production Natural Killer Cell Activation Immune Response Cytokine-mediated Signaling Pathway Interleukin-18 Receptor Binding Defense Response Inflammatory Response Interleukin-33 Receptor Activity Receptor Ligand Activity Extracellular Region Immune System Process Regulation Of Cytokine Production Trans-synaptic Signaling By Trans-synaptic Complex Interleukin-1 Receptor Activity Interleukin-33-mediated Signaling Pathway Regulation Of Interleukin-6 Production Cytokine Activity Positive Regulation Of NK T Cell Proliferation Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of T-helper 2 Cell Differentiation Cellular Response To Lipopolysaccharide Sleep Positive Regulation Of T-helper 1 Cell Cytokine Production Super Elongation Complex DEAD/H-box RNA Helicase Binding Positive Regulation Of NK T Cell Activation T-helper 1 Type Immune Response Type 2 Immune Response Regulation Of MRNA Export From Nucleus Positive Regulation Of Interleukin-5 Production Positive Regulation Of Natural Killer Cell Proliferation Interleukin-1 Receptor Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Regulation Of Postsynaptic Density Assembly Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Interleukin-18-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Natural Killer Cell Proliferation Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Membrane Disassembly Nuclear Membrane Disassembly Lamin Binding Lymphocyte Activation Interleukin-1-mediated Signaling Pathway Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Positive Regulation Of Interleukin-4 Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Interleukin-5 Production	Interleukin-18 Receptor Complex Interleukin-18 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Interleukin-18-mediated Signaling Pathway Cellular Response To Interleukin-18 Positive Regulation Of NF-kappaB Transcription Factor Activity Inflammatory Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Lymphocyte Mediated Immunity Interleukin-18 Binding Beta-galactoside Alpha-2,6-sialyltransferase Activity Response To Interleukin-18 Regulation Of DNA-binding Transcription Factor Activity Regulation Of Lymphocyte Mediated Immunity CARD8 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Lysosome Positive Regulation Of Immune Effector Process Signaling Receptor Activity Interleukin-1 Receptor Activity Positive Regulation Of T-helper 1 Cell Cytokine Production NLRP1 Inflammasome Complex Assembly Immune Response Adaptive Immune Response Sialylation Dipeptidyl-peptidase Activity Negative Regulation Of Bone Resorption Defense Response T-helper 1 Cell Differentiation Pyroptotic Cell Death Negative Regulation Of Bone Remodeling Sialyltransferase Activity Cytokine-mediated Signaling Pathway Positive Regulation Of T-helper 1 Type Immune Response Regulation Of Immune System Process Hydrolase Activity Neutrophil Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of T Cell Cytokine Production Aminopeptidase Activity Negative Regulation Of Osteoclast Differentiation