IL18R1

Name	interleukin 18 receptor 1
Structure
Novel Interactors	2 novel interactors: AFF3 AKAP8L
Interactors	4 interactors: CD48 IL18 IL1RAP IL37
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Interleukin-18 Receptor Complex
	Molecular Function	Interleukin-1 Receptor Activity Protein Binding Hydrolase Activity Signaling Receptor Activity Interleukin-18 Binding Interleukin-18 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating
	Biological Process	Adaptive Immune Response Inflammatory Response Immune Response Signal Transduction Natural Killer Cell Activation Positive Regulation Of Type II Interferon Production Interleukin-18-mediated Signaling Pathway T-helper 1 Cell Differentiation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways	Interleukin-37 signaling Interleukin-18 signaling
GWAS	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406 ) Allergic rhinitis ( 31361310 ) Allergic sensitization ( 23817571 ) Asthma ( 29273806 31959851 22561531 31619474 31361310 20860503 30929738 26620591 23028483 ) Asthma (adult onset) ( 31036433 30929738 ) Asthma (childhood onset) ( 29273806 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 26482879 23042114 ) Atypical femoral fracture in phosphonate treatment ( 31006051 ) Bisphosphonate-associated atypical femoral fracture ( 31006051 ) Blood protein levels ( 30072576 ) Celiac disease ( 20190752 18311140 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 21102463 28067908 ) Delirium ( 29631748 ) Eczema ( 31361310 ) Eosinophil count ( 27863252 32888494 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 32888494 ) Inflammatory bowel disease ( 28067908 23128233 ) Leprosy ( 25642632 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Nasal polyps ( 30643255 ) Neutrophil percentage of granulocytes ( 27863252 ) Neutrophil percentage of white cells ( 32888494 ) Pediatric autoimmune diseases ( 26301688 ) Polymyositis ( 26362759 ) Primary biliary cholangitis ( 26394269 ) Sum eosinophil basophil counts ( 27863252 )
Entrez ID	8809
HPRD ID	05138
Ensembl ID	ENSG00000115604
Uniprot IDs	B7ZKV7 Q13478
PDB IDs	3WO3 3WO4 4R6U
GO Terms Enriched among Interactors ?	Positive Regulation Of Interleukin-13 Production Natural Killer Cell Activation Immune Response Cytokine-mediated Signaling Pathway Interleukin-18 Receptor Binding Defense Response Inflammatory Response Interleukin-33 Receptor Activity Receptor Ligand Activity Extracellular Region Immune System Process Regulation Of Cytokine Production Trans-synaptic Signaling By Trans-synaptic Complex Interleukin-1 Receptor Activity Interleukin-33-mediated Signaling Pathway Regulation Of Interleukin-6 Production Cytokine Activity Positive Regulation Of NK T Cell Proliferation Cellular Response To Molecule Of Bacterial Origin Positive Regulation Of T-helper 2 Cell Differentiation Cellular Response To Lipopolysaccharide Sleep Positive Regulation Of T-helper 1 Cell Cytokine Production Super Elongation Complex DEAD/H-box RNA Helicase Binding Positive Regulation Of NK T Cell Activation T-helper 1 Type Immune Response Type 2 Immune Response Regulation Of MRNA Export From Nucleus Positive Regulation Of Interleukin-5 Production Positive Regulation Of Natural Killer Cell Proliferation Interleukin-1 Receptor Binding NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Regulation Of Postsynaptic Density Assembly Response To Molecule Of Bacterial Origin Response To Lipopolysaccharide Interleukin-18-mediated Signaling Pathway Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Regulation Of Natural Killer Cell Proliferation Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Membrane Disassembly Nuclear Membrane Disassembly Lamin Binding Lymphocyte Activation Interleukin-1-mediated Signaling Pathway Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Positive Regulation Of Interleukin-4 Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Interleukin-5 Production