SUCLG1 and SUCLG2

Number of citations of the paper that reports this interaction (PMID 10873456)
13

Data Source:
HPRD (in vitro)

		SUCLG1	SUCLG2
Gene Name		succinate-CoA ligase, alpha subunit	succinate-CoA ligase, GDP-forming, beta subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Plasma Membrane Succinate-CoA Ligase Complex (GDP-forming) Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Matrix Plasma Membrane Succinate-CoA Ligase Complex (GDP-forming)
	Molecular Function	ATP Citrate Synthase Activity Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity GTP Binding GDP Binding Poly(A) RNA Binding Protein Heterodimerization Activity Cofactor Binding	Succinate-CoA Ligase (GDP-forming) Activity ATP Binding GTP Binding GDP Binding Protein Heterodimerization Activity
	Biological Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process	Tricarboxylic Acid Cycle Succinyl-CoA Metabolic Process Succinate Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)	Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)
Drugs			Succinic acid
Diseases
GWAS			Corneal astigmatism ( 22144915) Height ( 20881960) IgE levels ( 23146381)
Protein-Protein Interactions		2 interactors: CHMP1B SUCLG2	2 interactors: GPR143 SUCLG1
Entrez ID		8802	8801
HPRD ID		18128	06799
Ensembl ID		ENSG00000163541	ENSG00000172340
Uniprot IDs		P53597	E9PDQ8 Q96I99
PDB IDs
Enriched GO Terms of Interacting Partners?		Succinyl-CoA Metabolic Process Regulation Of Mitotic Spindle Assembly Regulation Of Spindle Assembly Succinate Metabolic Process Regulation Of Mitotic Spindle Organization Cell Separation After Cytokinesis Mitotic Metaphase Plate Congression Metaphase Plate Congression Tricarboxylic Acid Cycle Regulation Of Centrosome Duplication Establishment Of Chromosome Localization Citrate Metabolic Process Regulation Of Centrosome Cycle Tricarboxylic Acid Metabolic Process Aerobic Respiration Acyl-CoA Metabolic Process Mitotic Sister Chromatid Segregation Vacuolar Transport Sister Chromatid Segregation Dicarboxylic Acid Metabolic Process Cytokinesis Nucleus Organization Regulation Of Mitotic Nuclear Division Regulation Of Microtubule Cytoskeleton Organization Cellular Respiration Regulation Of Microtubule-based Process Chromosome Segregation Regulation Of Cell Division	Eye Pigment Biosynthetic Process Succinyl-CoA Metabolic Process Eye Pigmentation Succinate Metabolic Process Calcium-mediated Signaling Using Intracellular Calcium Source Melanosome Organization Pigment Granule Organization Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Tricarboxylic Acid Cycle Regulation Of Calcium-mediated Signaling Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Cellular Pigmentation Pigment Biosynthetic Process Aerobic Respiration Acyl-CoA Metabolic Process Developmental Pigmentation Calcium-mediated Signaling Neuropeptide Signaling Pathway Dicarboxylic Acid Metabolic Process Pigmentation Phosphatidylinositol-mediated Signaling Second-messenger-mediated Signaling Cellular Respiration Visual Perception Sensory Perception Of Light Stimulus Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization
Tagcloud ?		autosomal c10orf2 cofactor controversial dguok dysmotility efficacious encephalomyopathic encephalopathy hepatocerebral heterogeneous hypotonia infancy mngie mpv17 mtdna myopathic neurogastrointestinal neurological neuropathy phenotypically polg recessive rrm2b sucla2 tk2 tymp typically weakness
Tagcloud (Difference) ?		autosomal c10orf2 cofactor controversial dguok dysmotility efficacious encephalomyopathic encephalopathy hepatocerebral heterogeneous hypotonia infancy mngie mpv17 mtdna myopathic neurogastrointestinal neurological neuropathy phenotypically polg recessive rrm2b sucla2 tk2 tymp typically weakness
Tagcloud (Intersection) ?