SUCLG1 and WDR36

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SUCLG1	WDR36
Description		succinate-CoA ligase GDP/ADP-forming subunit alpha	WD repeat domain 36
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Succinate-CoA Ligase Complex (ADP-forming) Succinate-CoA Ligase Complex (GDP-forming)	Nucleus Nucleoplasm Nucleolus Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome
	Molecular Function	Nucleotide Binding RNA Binding Catalytic Activity Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase (GDP-forming) Activity Protein Binding Ligase Activity	RNA Binding
	Biological Process	Tricarboxylic Acid Cycle Succinyl-CoA Catabolic Process	RRNA Processing Visual Perception Ribosome Biogenesis Ribosomal Small Subunit Biogenesis
Pathways		Citric acid cycle (TCA cycle)	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases		Mitochondrial DNA depletion syndrome (MDS)	Primary open angle glaucoma
GWAS		Coronary artery calcification ( 23870195) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota (functional units) ( 27694959)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 31361310 30013184) Allergic sensitization ( 23817571 30013184) Allergy ( 27182965) Asthma ( 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Childhood asthma with severe exacerbations ( 33328473) Eosinophil count ( 19198610) Eosinophilic esophagitis ( 34506852) Eosinophilic esophagitis (pediatric) ( 20208534) Medication use (antihistamines for systemic use) ( 31015401) Methadone dose in opioid dependence ( 28115739) Motor coordination ( 34177493) Periodontitis (PAL4Q3) ( 24024966) Self-reported allergy ( 23817569) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		5 interacting genes: CCAR2 CHMP1B SUCLG2 UBC WDR36	2 interacting genes: RNF10 SUCLG1
Entrez ID		8802	134430
HPRD ID		18128	10305
Ensembl ID		ENSG00000163541	ENSG00000134987
Uniprot IDs		P53597	Q8NI36
PDB IDs		6G4Q 6WCV 7MSR 7MSS 7MST 8Z02 8Z03	7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Succinate-CoA Ligase (ADP-forming) Activity Succinate-CoA Ligase Complex Succinate-CoA Ligase Complex (GDP-forming) Succinate-CoA Ligase (GDP-forming) Activity MIT Domain Binding DBIRD Complex	Succinate-CoA Ligase Complex (ADP-forming) Succinate-CoA Ligase Complex (GDP-forming) Succinate-CoA Ligase (GDP-forming) Activity Succinate-CoA Ligase (ADP-forming) Activity Succinyl-CoA Catabolic Process Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Succinyl-CoA Metabolic Process Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Myelination Tricarboxylic Acid Cycle Regulation Of Glial Cell Proliferation Negative Regulation Of Gliogenesis Regulation Of Myelination Postsynaptic Signal Transduction Protein Monoubiquitination Protein Autoubiquitination
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