TNFRSF10D and TNFRSF10A

Number of citations of the paper that reports this interaction (PMID 16319225)
42

Data Source:
HPRD (in vitro, in vivo)

		TNFRSF10D	TNFRSF10A
Gene Name		tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain	tumor necrosis factor receptor superfamily, member 10a
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity TRAIL Binding	Protease Binding Receptor Activity Death Receptor Activity Protein Binding Transcription Factor Binding TRAIL Binding
	Biological Process	Apoptotic Process Signal Transduction Negative Regulation Of Apoptotic Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors TRAIL-activated Apoptotic Signaling Pathway Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Regulation by c-FLIP Death Receptor Signalling TRAIL signaling Dimerization of procaspase-8 Caspase-8 activation by cleavage Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 20732625)	Age-related macular degeneration ( 21909106 23455636) Attention deficit hyperactivity disorder ( 20732625)
Protein-Protein Interactions		3 interactors: TNFRSF10A TNFRSF10B TNFSF10	15 interactors: BCL10 BTK CASP8 CD4 COL2A1 DAP3 FADD MADD MOAP1 RASSF1 RIPK1 TNFRSF10B TNFRSF10D TNFSF10 TRADD
Entrez ID		8793	8797
HPRD ID		04682	04679
Ensembl ID		ENSG00000173530
Uniprot IDs		Q9UBN6	O00220
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Positive Regulation Of Proteolysis Apoptotic Signaling Pathway Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of NIK/NF-kappaB Signaling NIK/NF-kappaB Signaling Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Proteolysis Cellular Response To Mechanical Stimulus Positive Regulation Of Intracellular Signal Transduction Extrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Positive Regulation Of Hydrolase Activity Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Apoptotic Process Response To Mechanical Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Catalytic Activity Regulation Of Cell Death TRAIL-activated Apoptotic Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Protein Kinase Activity	Regulation Of Extrinsic Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Regulation Of Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Zymogen Activation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Protein Processing Cellular Response To Stimulus Toll-like Receptor Signaling Pathway Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Signaling Cell Communication Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macrophage Differentiation Regulation Of Signal Transduction Regulation Of Lymphocyte Apoptotic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Catalytic Activity Regulation Of Proteolysis
Tagcloud ?			aa activator atm atmmutated b bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated
Tagcloud (Difference) ?			aa activator atm atmmutated b bax cdkn1a cll combinations elicit harboring hot lymphocytic maintained mdm2 next notch1 notch1mutated notch1mutations notch2 nutlin showing spot subgroup subset surprisingly tp53 tp53mutated
Tagcloud (Intersection) ?