SH3RF3

Description		SH3 domain containing ring finger 3
Image		No pdb structure
GO Annotations	Cellular Component
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of JNK Cascade Protein Autoubiquitination
Pathways
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Left-handedness ( 32989287) Monobrow thickness ( 26926045) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Rapid automised naming of digits ( 30741946) Scalp hair shape ( 26926045) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: ADAM15 BCL2L13 PAK2 RAC1
Entrez ID		344558
HPRD ID		19427
Ensembl ID		ENSG00000172985
Uniprot IDs		Q8TEJ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Cell Death Apoptotic Process Regulation Of Stress Fiber Assembly Programmed Cell Death Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Rho GDP-dissociation Inhibitor Binding Angiotensin-activated Signaling Pathway Involved In Heart Process Cell-matrix Adhesion Cell-substrate Adhesion Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Cell Adhesion Involved In Heart Morphogenesis Regulation Of Cell-matrix Adhesion Regulation Of Cell-substrate Adhesion Negative Regulation Of Receptor Binding Response To Hypobaric Hypoxia Regulation Of Ovarian Follicle Development Erythrocyte Enucleation Regulation Of Actin Filament Organization Kinocilium G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Auditory Receptor Cell Morphogenesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Hepatocyte Growth Factor Receptor Signaling Pathway Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Immune Response To Tumor Cell Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Cell Migration Regulation Of Interleukin-23 Production Regulation Of Neuron Maturation Thioesterase Binding Negative Regulation Of Cell Motility Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cellular Response To Phorbol 13-acetate 12-myristate Regulation Of Protein Phosphorylation Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Locomotion Positive Regulation Of Receptor Clustering Ruffle Assembly Negative Regulation Of Fibroblast Migration Response To Phorbol 13-acetate 12-myristate Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Focal Adhesion
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