SH3RF3 and BCL2L13

Number of citations of the paper that reports this interaction (PubMedID 24706805)
34

Data Source:
BioGRID (two hybrid)

		SH3RF3	BCL2L13
Description		SH3 domain containing ring finger 3	BCL2 like 13
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleus Mitochondrion Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of JNK Cascade Protein Autoubiquitination	Mitophagy Oxidative Phosphorylation Apoptotic Process Mitochondrion Organization Regulation Of Apoptotic Process Fat Cell Differentiation Canonical Glycolysis
Pathways
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Bitter taste perception (6-n-propylthiouracil) in obesity with metabolic syndrome ( 31005965) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Left-handedness ( 32989287) Monobrow thickness ( 26926045) Neurocognitive impairment in HIV-1 infection (dichotomous) ( 28447399) Rapid automised naming of digits ( 30741946) Scalp hair shape ( 26926045) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Eosinophil count ( 32888494) Granulocyte count ( 27863252) Hemoglobin levels ( 32327693) Interleukin-10 levels ( 22205395) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: ADAM15 BCL2L13 PAK2 RAC1	84 interacting genes: ACP5 ADIPOQ AGTRAP AIG1 APOD APP AQP1 ARL6IP1 ARLN BAZ2B BCL9 BET1 CAMLG CD53 CDC42 CDK5R1 CERS6 CLDN19 CRB3 DEFB127 ERG28 ERMP1 ETNK2 FAM210B FUS FXYD3 FZD7 GABARAPL2 GALNT2 GAST GTF2F1 HMOX2 HNRNPK IDI1 JAGN1 JPH4 LAT LAYN LPAR3 MAL MGMT MTNR1B NDRG4 NETO2 NINJ2 NR2C2AP NRBP1 PCBP1 PLLP PLN PLP1 PLPP4 PPT2 RPN2 SH3RF3 SLC30A8 SLC35A1 SLC35G5 SMARCD3 SMIM1 SPOCK1 SQLE SRSF3 STX12 STX8 TM6SF2 TMEM128 TMEM14C TMEM242 TMEM254 TMEM51 TMEM72 TMEM86A TMEM86B TMEM97 TMUB2 TNF TNMD TRARG1 TUBB UBC UPK1B VAMP3 VAMP4
Entrez ID		344558	23786
HPRD ID		19427	09822
Ensembl ID		ENSG00000172985	ENSG00000099968
Uniprot IDs		Q8TEJ3	A0A087WTL4 A0A087WW80 A0A087WX97 A0A0A0MR90 A8K5Y4 B2RB43 B7Z238 B7Z737 E9PDD6 F2Z2C3 F6VJB4 Q9BXK5
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Junction Organization Cell Death Apoptotic Process Regulation Of Stress Fiber Assembly Programmed Cell Death Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Rho GDP-dissociation Inhibitor Binding Angiotensin-activated Signaling Pathway Involved In Heart Process Cell-matrix Adhesion Cell-substrate Adhesion Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Cell Adhesion Involved In Heart Morphogenesis Regulation Of Cell-matrix Adhesion Regulation Of Cell-substrate Adhesion Negative Regulation Of Receptor Binding Response To Hypobaric Hypoxia Regulation Of Ovarian Follicle Development Erythrocyte Enucleation Regulation Of Actin Filament Organization Kinocilium G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Auditory Receptor Cell Morphogenesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Hepatocyte Growth Factor Receptor Signaling Pathway Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Immune Response To Tumor Cell Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Bicellular Tight Junction Assembly Negative Regulation Of Cell Migration Regulation Of Interleukin-23 Production Regulation Of Neuron Maturation Thioesterase Binding Negative Regulation Of Cell Motility Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cellular Response To Phorbol 13-acetate 12-myristate Regulation Of Protein Phosphorylation Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Locomotion Positive Regulation Of Receptor Clustering Ruffle Assembly Negative Regulation Of Fibroblast Migration Response To Phorbol 13-acetate 12-myristate Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Focal Adhesion	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Localization Within Membrane SNARE Complex Cellular Localization Response To Type II Interferon Structural Constituent Of Myelin Sheath Protein Binding Regulation Of Transport Alkenylglycerophosphocholine Hydrolase Activity Cellular Response To Type II Interferon SNAP Receptor Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Organelle Fusion Regulation Of Cellular Localization Phagocytic Vesicle Membrane Raft Regulation Of Chemokine Production Protein Localization To Membrane Protein Localization To Cell Periphery Vesicle Fusion Vesicle Organization Organelle Membrane Fusion Negative Regulation Of Blood Circulation Vesicle Docking Regulation Of Establishment Of Protein Localization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Protein Transport Response To Cytokine Protein Localization To Plasma Membrane Response To Peptide Positive Regulation Of Chemokine Production G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Membrane Raft Distribution Establishment Of Protein Localization To Membrane Recycling Endosome Organelle Localization By Membrane Tethering Membrane Raft Localization
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