HRK and CBR1

Data Source: HiPPIP (Novel)

		HRK	CBR1
Name		harakiri, BCL2 interacting protein	carbonyl reductase 1
Structure
GO Annotations	Cellular Component	Mitochondrion Membrane	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Binding	Carbonyl Reductase (NADPH) Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Prostaglandin E2 9-reductase Activity S-nitrosoglutathione Reductase (NADPH) Activity
	Biological Process	Apoptotic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Response To Potassium Ion Starvation Positive Regulation Of Release Of Cytochrome C From Mitochondria	Lipid Metabolic Process Xenobiotic Metabolic Process Glucocorticoid Metabolic Process Epithelial Cell Differentiation Vitamin K Metabolic Process Prostanoid Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		None	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		None	Rutin Resveratrol Heptaethylene glycol 2-(2-{2-[2-(2-{2-[2-(2-Ethoxy-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethoxy]-Ethoxy}-Ethoxy)-Ethanol, Polyethyleneglycol Peg400 Quercetin 3-(4-Amino-1-Tert-Butyl-1h-Pyrazolo[3,4-D]Pyrimidin-3-Yl)Phenol Curcumin Curcumin sulfate
GWAS		Alzheimer's disease (age of onset) ( 22005931 ) Brain morphology (MOSTest) ( 32665545 ) Brain structure ( 22504417 ) Dentate gyrus granule cell layer volume ( 30279459 ) Dentate gyrus molecular layer volume ( 30279459 ) HATA volume ( 30279459 ) Hippocampal subfield CA1 volume ( 30279459 ) Hippocampal subfield CA3 volume ( 30279459 ) Hippocampal subfield CA4 volume ( 30279459 ) Hippocampal tail volume ( 30279459 ) Hippocampal volume ( 28098162 22504421 ) Presubiculum volume ( 30279459 ) Presubiculum volume (corrected for total hippocampal volume) ( 30279459 ) Subcortical brain region volumes ( 25607358 ) Subiculum volume ( 30279459 ) Total hippocampal volume ( 30279459 )	Blood protein levels ( 30072576 ) Metabolite levels ( 23823483 ) Mitral valve prolapse ( 26301497 )
Novel Interactors		2 novel interactors: CBR1 MED1	5 novel interactors: CHAF1B HRK JAK1 LZTS1 PRKAR2B
Interacting Genes		7 interacting genes: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1	14 interacting genes: AGTR1 ERBB2 ERCC8 HTR2B OGT PAX6 PTPRF RANBP9 RNF26 RPS24 STAT5B UBC USP7 VHL
Entrez ID		8739	873
HPRD ID		04581	00267
Ensembl ID		ENSG00000135116	ENSG00000159228
Uniprot IDs		O00198	A0A384NL53 P16152
PDB IDs		2L58 2L5B 6XY4 7P0U	1WMA 2PFG 3BHI 3BHJ 3BHM 4Z3D
GO Terms Enriched among Interactors		Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway Channel Activity Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane Positive Regulation Of Apoptotic Process Mitochondrion Organization Positive Regulation Of Programmed Cell Death BH3 Domain Binding Apoptotic Signaling Pathway DNA Damage Response Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Apoptotic Process Negative Regulation Of Programmed Cell Death Cell Death Programmed Cell Death Negative Regulation Of Anoikis Intracellular Signal Transduction BAD-BCL-2 Complex Regulation Of Anoikis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Dendritic Cell Apoptotic Process Epithelial Cell Proliferation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Stress Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Dendritic Cell Apoptotic Process Cell Population Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Autophagy Mitochondrial Membrane Organization Regulation Of Autophagy Regulation Of Apoptotic Signaling Pathway Organelle Organization Mitochondrial Fusion Mitochondrion Hematopoietic Stem Cell Differentiation Programmed Cell Death Involved In Cell Development Regulation Of Extrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Regulation Of Cellular Response To Stress	Protein Modification Process Transcription-coupled Nucleotide-excision Repair Response To Stress Growth Hormone Receptor Signaling Pathway Via JAK-STAT Nucleoplasm Negative Regulation Of Autophagy Regulation Of TORC1 Signaling Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding Growth Hormone Receptor Signaling Pathway Regulation Of Lipid Metabolic Process Protein Ubiquitination Protein Metabolic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Developmental Process Regulation Of TOR Signaling Regulation Of Epithelial Cell Proliferation Negative Regulation Of Catabolic Process Protein Modification By Small Protein Conjugation Angiotensin Type I Receptor Activity Regulation Of Transcription-coupled Nucleotide-excision Repair Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Chondroitin Sulfate Proteoglycan Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Epithelial Cell Proliferation Proteolysis Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process