GNRHR and GPAA1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GNRHR	GPAA1
Description		gonadotropin releasing hormone receptor	glycosylphosphatidylinositol anchor attachment 1
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex
	Molecular Function	G Protein-coupled Receptor Activity Gonadotropin-releasing Hormone Receptor Activity Protein-hormone Receptor Activity	GPI-anchor Transamidase Activity Protein Binding GPI Anchor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Gonadotropin Secretion Cellular Response To Hormone Stimulus Cellular Response To Gonadotropin-releasing Hormone	GPI Anchor Biosynthetic Process Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis
Pathways		Hormone ligand-binding receptors G alpha (q) signalling events	Attachment of GPI anchor to uPAR
Drugs		Leuprolide Goserelin Cetrorelix Abarelix Gonadorelin Nafarelin Danazol Teverelix Sufugolix Degarelix Buserelin Ganirelix Histrelin Triptorelin Gestrinone Relugolix Elagolix Linzagolix
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Regular attendance at a pub or social club ( 29970889)	Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944)
Interacting Genes		5 interacting genes: GNRH1 GPAA1 RGS10 TMEM161A TSPAN7	10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13
Entrez ID		2798	8733
HPRD ID		00732	04334
Ensembl ID		ENSG00000109163	ENSG00000197858
Uniprot IDs		P30968	O43292
PDB IDs		7BR3	7W72 7WLD 8IMX 8IMY
Enriched GO Terms of Interacting Partners?		Response To Prolactin Negative Regulation Of Immature T Cell Proliferation Neurosecretory Vesicle Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Gonadotropin-releasing Hormone Receptor Binding Gonadotropin Hormone-releasing Hormone Activity Regulation Of Ovarian Follicle Development GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis Protein Retention In ER Lumen GPI Anchor Binding Estrous Cycle Negative Regulation Of Neuron Migration	GPI-anchor Transamidase Complex GPI Anchored Protein Biosynthesis Attachment Of GPI Anchor To Protein GPI Anchor Binding GPI-anchor Transamidase Activity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Glycerolipid Metabolic Process Phosphatidylinositol Metabolic Process Gamma-tubulin Binding Glycerophospholipid Biosynthetic Process Angiotensin Type I Receptor Activity Cis-trans Isomerase Activity Negative Regulation Of ARF Protein Signal Transduction Membrane Lipid Metabolic Process
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