GNRHR and RGS10

Number of citations of the paper that reports this interaction (PMID 12062898)
3

Data Source:
HPRD (in vivo)

		GNRHR	RGS10
Gene Name		gonadotropin-releasing hormone receptor	regulator of G-protein signaling 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane	Nucleus Cytoplasm Plasma Membrane Neuronal Cell Body Dendritic Spine Axon Terminus
	Molecular Function	Gonadotropin-releasing Hormone Receptor Activity Peptide Binding	GTPase Activator Activity
	Biological Process	G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Cellular Response To Gonadotropin-releasing Hormone	Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Hormone ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs		Leuprolide Goserelin Cetrorelix Abarelix Gonadorelin Nafarelin Danazol Degarelix Buserelin
Diseases
GWAS
Protein-Protein Interactions		2 interactors: GNRH1 RGS10	9 interactors: ADRB2 APP CALM1 GNAI1 GNAI3 GNAO1 GNAZ GNRHR PRKACA
Entrez ID		2798	6001
HPRD ID		00732	04172
Ensembl ID			ENSG00000148908
Uniprot IDs		P30968	O43665
PDB IDs			2DLR 2I59 2IHB
Enriched GO Terms of Interacting Partners?		Regulation Of Ovarian Follicle Development Regulation Of Female Gonad Development	G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Adenylate Cyclase Activity Platelet Activation Regulation Of Cyclase Activity Cell Surface Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Activation Of Adenylate Cyclase Activity Blood Coagulation Hemostasis Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Regulation Of Body Fluid Levels Wound Healing Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Signal Transduction Positive Regulation Of CAMP Metabolic Process Cell Activation Response To Wounding Signaling Cell Communication Positive Regulation Of Cyclic Nucleotide Metabolic Process Response To Organonitrogen Compound Cellular Response To Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Protein Binding Regulation Of Muscle Contraction Regulation Of Heart Contraction Negative Regulation Of Adenylate Cyclase Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Lyase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Stress Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Calcium Ion Transport Synaptic Transmission Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of CAMP Biosynthetic Process Regulation Of Ion Transport Rhodopsin Mediated Signaling Pathway Negative Regulation Of CAMP Metabolic Process Regulation Of Catalytic Activity Response To Stimulus Vesicle-mediated Transport Regulation Of Phosphorus Metabolic Process Negative Regulation Of Nucleotide Metabolic Process
Tagcloud ?		aas aass abused anabolic androgenic arr19 cyp11a1 cyp17a1 dax1 disturbed enanthate hsd17b4 hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo	alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs12 soy sscs supplementation supplements tolerability unsatisfactory
Tagcloud (Difference) ?		aas aass abused anabolic androgenic arr19 cyp11a1 cyp17a1 dax1 disturbed enanthate hsd17b4 hsd3b1 hsd3b5 insl3 intramuscular leydig lhcgr milieu oppositely prka prlr1 prlr2 prolactin star steroidogenesis steroidogenic testosterone tspo	alveolar avenues bones combat craniofacial destruction forearm isoflavone menopausal microbe mkp multipotent nfatc1 oscillation oscillations osteoclast osteoclastogenesis periodontal periodontitis periosteum relate resorption rgs12 soy sscs supplementation supplements tolerability unsatisfactory
Tagcloud (Intersection) ?