GNRHR and TSPAN7

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		GNRHR	TSPAN7
Description		gonadotropin releasing hormone receptor	tetraspanin 7
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Gonadotropin-releasing Hormone Receptor Activity Protein-hormone Receptor Activity	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Gonadotropin Secretion Cellular Response To Hormone Stimulus Cellular Response To Gonadotropin-releasing Hormone
Pathways		Hormone ligand-binding receptors G alpha (q) signalling events	Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors
Drugs		Leuprolide Goserelin Cetrorelix Abarelix Gonadorelin Nafarelin Danazol Teverelix Sufugolix Degarelix Buserelin Ganirelix Histrelin Triptorelin Gestrinone Relugolix Elagolix Linzagolix
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)	Non-syndromic X-linked mental retardation
GWAS		Regular attendance at a pub or social club ( 29970889)	White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: GNRH1 GPAA1 RGS10 TMEM161A TSPAN7	27 interacting genes: ADRB2 BBS1 BTG3 BUD31 CACNA1A CCR2 CCR9 CHRM2 CHRM4 CREB3 DRD2 FAM209A FYTTD1 GNRHR GPR152 GPR35 GRIA2 GRIA3 HTR4 ITGB1 LHFPL5 LMNA LTB4R2 MEOX2 OXTR PICK1 SMO
Entrez ID		2798	7102
HPRD ID		00732	02107
Ensembl ID		ENSG00000109163	ENSG00000156298
Uniprot IDs		P30968	P41732
PDB IDs		7BR3
Enriched GO Terms of Interacting Partners?		Response To Prolactin Negative Regulation Of Immature T Cell Proliferation Neurosecretory Vesicle Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane Gonadotropin-releasing Hormone Receptor Binding Gonadotropin Hormone-releasing Hormone Activity Regulation Of Ovarian Follicle Development GPI-anchor Transamidase Activity GPI-anchor Transamidase Complex Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis Protein Retention In ER Lumen GPI Anchor Binding Estrous Cycle Negative Regulation Of Neuron Migration	G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Biological Quality Chemical Synaptic Transmission Plasma Membrane Trans-synaptic Signaling Synaptic Signaling Cell-cell Signaling Signaling Endocytic Vesicle Membrane Cell Communication Dendrite Chemokine Receptor Activity Multicellular Organismal-level Homeostasis Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Amyloid-beta Binding Positive Regulation Of Neuroblast Proliferation Ionotropic Glutamate Receptor Signaling Pathway Neural Precursor Cell Proliferation G Protein-coupled Acetylcholine Receptor Activity Regulation Of Locomotion Postsynaptic Membrane Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Membrane Positive Regulation Of Neurotransmitter Uptake AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Signaling Pathway Regulation Of Neuroblast Proliferation Neuroblast Proliferation Signal Transduction Patched Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Cellular Defense Response Glutamate Receptor Signaling Pathway Synapse Positive Regulation Of Neural Precursor Cell Proliferation Ciliary Membrane G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dendritic Spine Positive Regulation Of Cytosolic Calcium Ion Concentration Glutamate-gated Receptor Activity Negative Regulation Of Adenylate Cyclase Activity Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Motility Regulation Of System Process Cilium
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