DNAH11 and IL6

		DNAH11	IL6
Description		dynein axonemal heavy chain 11	interleukin 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytoskeleton Microtubule Cilium Axoneme Dynein Complex Motile Cilium Cell Projection 9+0 Motile Cilium 9+2 Motile Cilium Proximal Portion Of Axoneme	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Interleukin-6 Receptor Complex
	Molecular Function	Nucleotide Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding
	Biological Process	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Regulation Of Cilium Beat Frequency Microtubule-based Movement Determination Of Left/right Symmetry Heart Development Learning Or Memory Flagellated Sperm Motility Determination Of Left/right Asymmetry In Nervous System Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cilium Movement Involved In Cell Motility Cardiac Septum Morphogenesis Protein Localization To Motile Cilium	Neutrophil Apoptotic Process Germinal Center B Cell Differentiation Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Immunoglobulin Production Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Inflammatory Response Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Vascular Endothelial Growth Factor Production Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lipid Storage Response To Activity Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Activation Endocrine Pancreas Development Neuron Projection Development Response To Peptidoglycan Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-21 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Blood-brain Barrier Positive Regulation Of T Cell Proliferation Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Regulation Of Protein Transport Positive Regulation Of Lymphocyte Activation Response To Glucocorticoid Defense Response To Virus Positive Regulation Of Glial Cell Proliferation T Follicular Helper Cell Differentiation Regulation Of Astrocyte Activation Neuron Cellular Homeostasis Glucagon Secretion Regulation Of Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide T-helper 17 Cell Lineage Commitment Hepatocyte Proliferation Positive Regulation Of Extracellular Matrix Disassembly Inflammatory Response To Wounding Liver Regeneration Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Platelet Aggregation Positive Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of MiRNA Transcription Regulation Of Microglial Cell Activation Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways			Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response
Drugs			Ginseng YSIL6 VX-702 Atiprimod CRx-139 Andrographolide Siltuximab Polaprezinc Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Binimetinib Dilmapimod Olokizumab
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome	Graft-versus-host disease
GWAS		Apolipoprotein B levels ( 32203549) Bipolar disorder ( 31043756) Bone mineral density (hip) ( 30172743) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Cholesterol, total ( 19060911 20686565 24097068 25961943) Cognitive decline (age-related) ( 24468470) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821) LDL cholesterol ( 19060911 30275531 20686565 25961943 24097068) LDL cholesterol levels ( 32203549 28334899) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731 33339817) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227) Multiple myeloma ( 26007630 22120009) Multiple myeloma and monoclonal gammopathy ( 26007630) PR interval ( 32439900) Recurrent major depressive disorder x sex interaction ( 34099189) Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum total polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Subcortical volume (MOSTest) ( 32665545) Total cholesterol levels ( 30275531 33339817 28334899) Total ventricular volume ( 21116278) Whole-brain volume ( 21116278)	Asthma ( 32296059 31959851 31619474 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) C-reactive protein ( 21196492) C-reactive protein levels ( 30388399) Calcific aortic valve stenosis ( 32141789) Cerebrospinal fluid clusterin levels in APOEe4- carriers ( 26545630) Dialysis-related mortality ( 21546767) Fibrinogen ( 23969696) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Longevity ( 26912274) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Pulse pressure ( 30578418 30224653) Takayasu arteritis ( 25604533)
Interacting Genes			8 interacting genes: ELAVL1 HNRNPD IL6R IL6ST PTHLH SH3GL2 ZBTB16 ZC3H12A
Entrez ID		8701	3569
HPRD ID		09134	00970
Ensembl ID		ENSG00000105877	ENSG00000136244
Uniprot IDs		H9NAJ7 H9NAJ8 Q96DT5 Q96NT7	B4DNQ5 B4DVM1 B5MC21 B5MCZ3 P05231 Q75MH2
PDB IDs			1ALU 1IL6 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC 7NXZ 8D82 8QY5 8QY6 8YWQ 8YWR
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of MiRNA Processing Negative Regulation Of Primary MiRNA Processing Inflammatory Cell Apoptotic Process Glucagon Secretion Response To Peptidoglycan Vascular Endothelial Growth Factor Production Positive Regulation Of Apoptotic DNA Fragmentation Myeloid Cell Apoptotic Process Inflammatory Response To Wounding Hepatocyte Proliferation Negative Regulation Of Bone Resorption Interleukin-6 Receptor Complex Neutrophil Apoptotic Process Negative Regulation Of Bone Remodeling Germinal Center B Cell Differentiation Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Interleukin-21 Production Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Positive Regulation Of T-helper 2 Cell Cytokine Production Endocrine Pancreas Development Regulation Of Microglial Cell Activation Positive Regulation Of Extracellular Matrix Disassembly Interleukin-6 Receptor Binding Positive Regulation Of Platelet Aggregation T Follicular Helper Cell Differentiation Negative Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of Regulatory NcRNA Processing Negative Regulation Of Collagen Biosynthetic Process Regulation Of Astrocyte Activation Hepatic Immune Response Regulation Of Glucagon Secretion Negative Regulation Of MiRNA Processing Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Serine-type Carboxypeptidase Activity Gamma-glutamylcyclotransferase Activity Positive Regulation Of Type 2 Immune Response T-helper Cell Lineage Commitment CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Mediated Immunity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Glial Cell Proliferation Monocyte Chemotaxis Negative Regulation Of Lipid Storage	Interleukin-6 Binding Interleukin-6 Receptor Activity MRNA 3'-UTR AU-rich Region Binding Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-6 Receptor Binding MRNA Destabilization RNA Destabilization Positive Regulation Of Platelet Aggregation T-helper 17 Cell Lineage Commitment Positive Regulation Of MRNA Catabolic Process Interleukin-6-mediated Signaling Pathway 3'-UTR-mediated MRNA Destabilization T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of MRNA Metabolic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Response To Ether Alpha-beta T Cell Lineage Commitment Response To Salt CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Platelet Aggregation Regulation Of Cell-cell Adhesion T Cell Lineage Commitment Regulation Of MRNA Stability MiRNA Binding Regulation Of RNA Stability Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression MRNA Binding Cytokine Receptor Activity Regulation Of Cell Activation Regulation Of Chondrocyte Differentiation Regulation Of Platelet Activation Positive Regulation Of Autophagosome Size Negative Regulation Of Macromolecule Biosynthetic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Ciliary Neurotrophic Factor Binding Proximal Portion Of Axoneme Positive Regulation Of Reactive Oxygen Species Metabolic Process MRNA Stabilization Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?