IL6 and ZC3H12A

Number of citations of the paper that reports this interaction (PubMedID 29743536)
41

Data Source:
BioGRID (pull down)

		IL6	ZC3H12A
Description		interleukin 6	zinc finger CCCH-type containing 12A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Interleukin-6 Receptor Complex	P-body Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytoskeleton Membrane Rough Endoplasmic Reticulum Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding	DNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity RNA Exonuclease Activity RNA Nuclease Activity Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Hydrolase Activity MiRNA Binding RNA Stem-loop Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Metal Ion Binding
	Biological Process	Neutrophil Apoptotic Process Germinal Center B Cell Differentiation Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Immunoglobulin Production Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Inflammatory Response Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Vascular Endothelial Growth Factor Production Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lipid Storage Response To Activity Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Activation Endocrine Pancreas Development Neuron Projection Development Response To Peptidoglycan Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-21 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Blood-brain Barrier Positive Regulation Of T Cell Proliferation Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Regulation Of Protein Transport Positive Regulation Of Lymphocyte Activation Response To Glucocorticoid Defense Response To Virus Positive Regulation Of Glial Cell Proliferation T Follicular Helper Cell Differentiation Regulation Of Astrocyte Activation Neuron Cellular Homeostasis Glucagon Secretion Regulation Of Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide T-helper 17 Cell Lineage Commitment Hepatocyte Proliferation Positive Regulation Of Extracellular Matrix Disassembly Inflammatory Response To Wounding Liver Regeneration Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Platelet Aggregation Positive Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of MiRNA Transcription Regulation Of Microglial Cell Activation Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Immune System Process Immune Response-activating Signaling Pathway MRNA Catabolic Process Apoptotic Process Inflammatory Response DNA Damage Response Nervous System Development Regulation Of Gene Expression Positive Regulation Of Autophagy MiRNA Catabolic Process Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Lipid Storage Protein Deubiquitination Cell Differentiation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Genome Replication Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Complex Oligomerization Defense Response To Virus Negative Regulation Of Cardiac Muscle Contraction Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of P38MAPK Cascade Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Deubiquitination Cellular Response To Sodium Arsenite Cellular Response To Ionomycin Cellular Response To Chemokine Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of MiRNA Catabolic Process
Pathways		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response	Regulation of CDH19 Expression and Function
Drugs		Ginseng YSIL6 VX-702 Atiprimod CRx-139 Andrographolide Siltuximab Polaprezinc Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Binimetinib Dilmapimod Olokizumab
Diseases		Graft-versus-host disease
GWAS		Asthma ( 32296059 31959851 31619474 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) C-reactive protein ( 21196492) C-reactive protein levels ( 30388399) Calcific aortic valve stenosis ( 32141789) Cerebrospinal fluid clusterin levels in APOEe4- carriers ( 26545630) Dialysis-related mortality ( 21546767) Fibrinogen ( 23969696) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Longevity ( 26912274) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Pulse pressure ( 30578418 30224653) Takayasu arteritis ( 25604533)	Eyebrow thickness ( 26926045) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		8 interacting genes: ELAVL1 HNRNPD IL6R IL6ST PTHLH SH3GL2 ZBTB16 ZC3H12A	19 interacting genes: AHSP AIMP2 BTRC CYFIP2 DNAJB13 EP300 HIF1A IKBKG IL6 IRAK2 KPNA2 P4HA3 SHBG SMAD3 TANK TRIM55 TRIM63 UBC ZC3H12D
Entrez ID		3569	80149
HPRD ID		00970	08021
Ensembl ID		ENSG00000136244	ENSG00000163874
Uniprot IDs		B4DNQ5 B4DVM1 B5MC21 B5MCZ3 P05231 Q75MH2	A0A1W2PQC8 Q5D1E8
PDB IDs		1ALU 1IL6 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC 7NXZ 8D82 8QY5 8QY6 8YWQ 8YWR	3V32 3V33 3V34
Enriched GO Terms of Interacting Partners?		Interleukin-6 Binding Interleukin-6 Receptor Activity MRNA 3'-UTR AU-rich Region Binding Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-6 Receptor Binding MRNA Destabilization RNA Destabilization Positive Regulation Of Platelet Aggregation T-helper 17 Cell Lineage Commitment Positive Regulation Of MRNA Catabolic Process Interleukin-6-mediated Signaling Pathway 3'-UTR-mediated MRNA Destabilization T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of MRNA Metabolic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Response To Ether Alpha-beta T Cell Lineage Commitment Response To Salt CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Platelet Aggregation Regulation Of Cell-cell Adhesion T Cell Lineage Commitment Regulation Of MRNA Stability MiRNA Binding Regulation Of RNA Stability Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression MRNA Binding Cytokine Receptor Activity Regulation Of Cell Activation Regulation Of Chondrocyte Differentiation Regulation Of Platelet Activation Positive Regulation Of Autophagosome Size Negative Regulation Of Macromolecule Biosynthetic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Ciliary Neurotrophic Factor Binding Proximal Portion Of Axoneme Positive Regulation Of Reactive Oxygen Species Metabolic Process MRNA Stabilization Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Biosynthetic Process	Canonical NF-kappaB Signal Transduction Response To Interleukin-1 Non-canonical NF-kappaB Signal Transduction Apoptotic Process Regulation Of Glycolytic Process Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Nuclear Receptor Binding Positive Regulation Of Signal Transduction Transcription Coactivator Binding Ubiquitin Protein Ligase Binding Vascular Endothelial Growth Factor Production Positive Regulation Of MiRNA Transcription Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Cell Death Positive Regulation Of MiRNA Metabolic Process Regulation Of Cytokine-mediated Signaling Pathway Response To Virus Hemoglobin Metabolic Process Positive Regulation Of Proteolysis Regulation Of ATP Metabolic Process Immune System Process Cellular Response To Virus Regulation Of MiRNA Transcription T-helper 17 Cell Lineage Commitment TOR Signaling Regulation Of Purine Nucleotide Metabolic Process Regulation Of Intracellular Signal Transduction Response To Other Organism Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cytoplasm DNA-binding Transcription Repressor Activity T-helper Cell Lineage Commitment Positive Regulation Of Protein Metabolic Process Beta-catenin Binding Positive Regulation Of Cytokine Production Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment Positive Regulation Of Catabolic Process Positive Regulation Of Metabolic Process
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