IL6

Description		interleukin 6
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Interleukin-6 Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding
	Biological Process	Neutrophil Apoptotic Process Germinal Center B Cell Differentiation Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Immunoglobulin Production Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Inflammatory Response Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Vascular Endothelial Growth Factor Production Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lipid Storage Response To Activity Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Activation Endocrine Pancreas Development Neuron Projection Development Response To Peptidoglycan Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-21 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Blood-brain Barrier Positive Regulation Of T Cell Proliferation Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Regulation Of Protein Transport Positive Regulation Of Lymphocyte Activation Response To Glucocorticoid Defense Response To Virus Positive Regulation Of Glial Cell Proliferation T Follicular Helper Cell Differentiation Regulation Of Astrocyte Activation Neuron Cellular Homeostasis Glucagon Secretion Regulation Of Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide T-helper 17 Cell Lineage Commitment Hepatocyte Proliferation Positive Regulation Of Extracellular Matrix Disassembly Inflammatory Response To Wounding Liver Regeneration Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Platelet Aggregation Positive Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of MiRNA Transcription Regulation Of Microglial Cell Activation Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response
Drugs		Ginseng YSIL6 VX-702 Atiprimod CRx-139 Andrographolide Siltuximab Polaprezinc Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Binimetinib Dilmapimod Olokizumab
Diseases		Graft-versus-host disease
GWAS		Asthma ( 32296059 31959851 31619474 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) C-reactive protein ( 21196492) C-reactive protein levels ( 30388399) Calcific aortic valve stenosis ( 32141789) Cerebrospinal fluid clusterin levels in APOEe4- carriers ( 26545630) Dialysis-related mortality ( 21546767) Fibrinogen ( 23969696) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Longevity ( 26912274) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Pulse pressure ( 30578418 30224653) Takayasu arteritis ( 25604533)
Novel Interacting Genes		2 novel interacting genes: - DNAH11
Interacting Genes		8 interacting genes: ELAVL1 HNRNPD IL6R IL6ST PTHLH SH3GL2 ZBTB16 ZC3H12A
Entrez ID		3569
HPRD ID		00970
Ensembl ID		ENSG00000136244
Uniprot IDs		B4DNQ5 B4DVM1 B5MC21 B5MCZ3 P05231 Q75MH2
PDB IDs		1ALU 1IL6 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC 7NXZ 8D82 8QY5 8QY6 8YWQ 8YWR
Enriched GO Terms of Interacting Partners?		Interleukin-6 Binding Interleukin-6 Receptor Activity MRNA 3'-UTR AU-rich Region Binding Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-6 Receptor Binding MRNA Destabilization RNA Destabilization Positive Regulation Of Platelet Aggregation T-helper 17 Cell Lineage Commitment Positive Regulation Of MRNA Catabolic Process Interleukin-6-mediated Signaling Pathway 3'-UTR-mediated MRNA Destabilization T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of MRNA Metabolic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Response To Ether Alpha-beta T Cell Lineage Commitment Response To Salt CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Platelet Aggregation Regulation Of Cell-cell Adhesion T Cell Lineage Commitment Regulation Of MRNA Stability MiRNA Binding Regulation Of RNA Stability Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression MRNA Binding Cytokine Receptor Activity Regulation Of Cell Activation Regulation Of Chondrocyte Differentiation Regulation Of Platelet Activation Positive Regulation Of Autophagosome Size Negative Regulation Of Macromolecule Biosynthetic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Ciliary Neurotrophic Factor Binding Proximal Portion Of Axoneme Positive Regulation Of Reactive Oxygen Species Metabolic Process MRNA Stabilization Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Biosynthetic Process
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