IL6 and IL6ST

Number of citations of the paper that reports this interaction (PubMedID 14557255)
0

Data Source:
HPRD (in vivo)

		IL6	IL6ST
Description		interleukin 6	interleukin 6 cytokine family signal transducer
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Interleukin-6 Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Receptor Complex Cell Body Membrane Raft Extracellular Exosome Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity Identical Protein Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Coreceptor Activity Growth Factor Binding Cytokine Binding Interleukin-11 Binding Interleukin-6 Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding Interleukin-27 Receptor Activity Scaffold Protein Binding
	Biological Process	Neutrophil Apoptotic Process Germinal Center B Cell Differentiation Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Immunoglobulin Production Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Inflammatory Response Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Vascular Endothelial Growth Factor Production Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lipid Storage Response To Activity Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Activation Endocrine Pancreas Development Neuron Projection Development Response To Peptidoglycan Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-21 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Blood-brain Barrier Positive Regulation Of T Cell Proliferation Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Bone Resorption Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Regulation Of Protein Transport Positive Regulation Of Lymphocyte Activation Response To Glucocorticoid Defense Response To Virus Positive Regulation Of Glial Cell Proliferation T Follicular Helper Cell Differentiation Regulation Of Astrocyte Activation Neuron Cellular Homeostasis Glucagon Secretion Regulation Of Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide T-helper 17 Cell Lineage Commitment Hepatocyte Proliferation Positive Regulation Of Extracellular Matrix Disassembly Inflammatory Response To Wounding Liver Regeneration Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Platelet Aggregation Positive Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of MiRNA Transcription Regulation Of Microglial Cell Activation Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Cell Differentiation Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Intestinal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Platelet Aggregation
Pathways		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response	Interleukin-6 signaling Interleukin-6 signaling IL-6-type cytokine receptor ligand interactions Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs		Ginseng YSIL6 VX-702 Atiprimod CRx-139 Andrographolide Siltuximab Polaprezinc Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Binimetinib Dilmapimod Olokizumab
Diseases		Graft-versus-host disease
GWAS		Asthma ( 32296059 31959851 31619474 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) C-reactive protein ( 21196492) C-reactive protein levels ( 30388399) Calcific aortic valve stenosis ( 32141789) Cerebrospinal fluid clusterin levels in APOEe4- carriers ( 26545630) Dialysis-related mortality ( 21546767) Fibrinogen ( 23969696) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Longevity ( 26912274) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Pulse pressure ( 30578418 30224653) Takayasu arteritis ( 25604533)	Blood protein levels ( 30072576) Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Mean spheric corpuscular volume ( 32888494) Type 1 diabetes ( 34127860)
Interacting Genes		8 interacting genes: ELAVL1 HNRNPD IL6R IL6ST PTHLH SH3GL2 ZBTB16 ZC3H12A	35 interacting genes: AR CDK9 CMYA5 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP1 KCNIP3 LIF LIFR MAGEA11 NEDD4L OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTA SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1
Entrez ID		3569	3572
HPRD ID		00970	02824
Ensembl ID		ENSG00000136244	ENSG00000134352
Uniprot IDs		B4DNQ5 B4DVM1 B5MC21 B5MCZ3 P05231 Q75MH2	A0A0A0N0L2 A0A0A0N0L5 A0A8V8TMJ9 A0A8V8TNI4 P40189 Q17RA0
PDB IDs		1ALU 1IL6 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC 7NXZ 8D82 8QY5 8QY6 8YWQ 8YWR	1BJ8 1BQU 1I1R 1P9M 1PVH 3L5H 3L5I 3L5J 7U7N 8D6A 8D74 8D7R 8D82 8D85 8DPS 8DPT 8DPU 8UPA 8V29 8V2A
Enriched GO Terms of Interacting Partners?		Interleukin-6 Binding Interleukin-6 Receptor Activity MRNA 3'-UTR AU-rich Region Binding Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Receptor Activity Interleukin-11 Binding Ciliary Neurotrophic Factor-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-6 Receptor Binding MRNA Destabilization RNA Destabilization Positive Regulation Of Platelet Aggregation T-helper 17 Cell Lineage Commitment Positive Regulation Of MRNA Catabolic Process Interleukin-6-mediated Signaling Pathway 3'-UTR-mediated MRNA Destabilization T-helper Cell Lineage Commitment Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of MRNA Metabolic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Response To Ether Alpha-beta T Cell Lineage Commitment Response To Salt CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Platelet Aggregation Regulation Of Cell-cell Adhesion T Cell Lineage Commitment Regulation Of MRNA Stability MiRNA Binding Regulation Of RNA Stability Negative Regulation Of Gene Expression Positive Regulation Of Gene Expression MRNA Binding Cytokine Receptor Activity Regulation Of Cell Activation Regulation Of Chondrocyte Differentiation Regulation Of Platelet Activation Positive Regulation Of Autophagosome Size Negative Regulation Of Macromolecule Biosynthetic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Ciliary Neurotrophic Factor Binding Proximal Portion Of Axoneme Positive Regulation Of Reactive Oxygen Species Metabolic Process MRNA Stabilization Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Biosynthetic Process	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Positive Regulation Of Phosphate Metabolic Process T-helper 17 Cell Lineage Commitment Regulation Of Cell Population Proliferation Ciliary Neurotrophic Factor-mediated Signaling Pathway Signal Transduction Interleukin-6-mediated Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway T-helper Cell Lineage Commitment Negative Regulation Of Apoptotic Process Interleukin-11-mediated Signaling Pathway Phosphotyrosine Residue Binding CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Programmed Cell Death Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Alpha-beta T Cell Lineage Commitment Positive Regulation Of Peptidyl-tyrosine Phosphorylation CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Cell Adhesion Regulation Of MAPK Cascade Regulation Of Apoptotic Process T Cell Lineage Commitment Receptor Complex Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Ciliary Neurotrophic Factor Receptor Activity Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Gene Expression Regulation Of Cell-cell Adhesion Regulation Of Defense Response Regulation Of Macromolecule Metabolic Process Cytokine Receptor Activity Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction
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