IL6 and IL6ST

Number of citations of the paper that reports this interaction (PMID 14557255)
0

Data Source:
HPRD (in vivo)

		IL6	IL6ST
Gene Name		interleukin 6	interleukin 6 signal transducer
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Interleukin-6 Receptor Complex External Side Of Plasma Membrane	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Extracellular Vesicular Exosome Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity	Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Interleukin-27 Receptor Activity
	Biological Process	Neutrophil Apoptotic Process Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Protein Kinase Activity Acute-phase Response Inflammatory Response Humoral Immune Response Aging Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Response To Heat Response To Cold Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Lipid Storage Response To Auditory Stimulus Cell Growth Cytokine-mediated Signaling Pathway Platelet Activation Response To Caffeine Endocrine Pancreas Development Neuron Projection Development Response To Nutrient Levels Response To Peptidoglycan Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Response To Insulin Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of T Cell Proliferation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Glucose Homeostasis Defense Response To Protozoan Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Amino Acid Positive Regulation Of MAPK Cascade Negative Regulation Of Chemokine Biosynthetic Process Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Nitric Oxide Biosynthetic Process Cell Redox Homeostasis Negative Regulation Of Fat Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Translation Positive Regulation Of DNA Replication Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JAK-STAT Cascade Response To Antibiotic Muscle Cell Cellular Homeostasis Bone Remodeling Negative Regulation Of Hormone Secretion Negative Regulation Of Muscle Organ Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Glucocorticoid Response To Calcium Ion Response To Electrical Stimulus Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Transmission Of Nerve Impulse Branching Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus T-helper 17 Cell Lineage Commitment Negative Regulation Of Neuron Death Positive Regulation Of STAT Protein Import Into Nucleus Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Viral Process Cytokine-mediated Signaling Pathway Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Interleukin-6-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways		Signaling by GPCR Signaling by FGFR in disease Cellular Senescence FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions TRIF-mediated TLR3/TLR4 signaling SHC-related events triggered by IGF1R ERK1 activation GRB2 events in EGFR signaling Senescence-Associated Secretory Phenotype (SASP) Signaling by ERBB4 ERK1 activation Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance ERK activation IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade Interleukin-6 signaling IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Activated TLR4 signalling MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade ERK2 activation Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades SHC1 events in EGFR signaling Toll Like Receptor 10 (TLR10) Cascade FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK2 activation	Signaling by Interleukins Interleukin-6 signaling Cytokine Signaling in Immune system
Drugs		Ginseng
Diseases
GWAS		C-reactive protein ( 21196492) Dialysis-related mortality ( 21546767)	Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		5 interactors: IL6R IL6ST PTHLH SH3GL2 ZBTB16	31 interactors: AR CDK9 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP3 LIF LIFR MAGEA11 OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1
Entrez ID		3569	3572
HPRD ID		00970	02824
Ensembl ID		ENSG00000136244	ENSG00000134352
Uniprot IDs		B4DNQ5 B4DVM1 B5MC21 P05231 Q75MH2	D6RH03 P40189 Q17RA0
PDB IDs		1ALU 1IL6 1N2Q 1P9M 2IL6	1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Ossification Interleukin-6-mediated Signaling Pathway Regulation Of Ossification Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of Cell Proliferation Regulation Of Chondrocyte Differentiation Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Regulation Of JAK-STAT Cascade System Development Interleukin-11-mediated Signaling Pathway Nipple Sheath Formation Mammary Gland Bud Elongation Regulation Of Osteoblast Differentiation Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Cell Proliferation Hepatic Immune Response Interleukin-27-mediated Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Differentiation Positive Regulation Of Immune System Process Negative Regulation Of Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of NK T Cell Differentiation Mammary Gland Bud Morphogenesis Positive Regulation Of Cell-cell Adhesion Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of Activation Of Janus Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Positive Regulation Of Cell Activation Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Multicellular Organismal Metabolic Process Cell Differentiation	Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Response To Cytokine Cellular Response To Organic Substance Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Cell Proliferation Cell Communication Response To Organic Substance Positive Regulation Of Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Response To Stimulus Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Defense Response Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Phosphorus Metabolic Process Immune System Process Regulation Of Protein Metabolic Process JAK-STAT Cascade Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Immune Response Regulation Of Cellular Ketone Metabolic Process Leukocyte Migration Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Regulation Of JAK-STAT Cascade
Tagcloud ?		adapted antisera biosensors biotinylated catalyzes coated colored colorless conjugated densitometry easily electrophoretic ideal immunosorbent interfere lends manipulation oligonucleotides optical peroxidase plate plates reader readily recognised robotic shift streptavidin throughput	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		adapted antisera biosensors biotinylated catalyzes coated colored colorless conjugated densitometry easily electrophoretic ideal immunosorbent interfere lends manipulation oligonucleotides optical peroxidase plate plates reader readily recognised robotic shift streptavidin throughput	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?