DNAH11 and GGCT

Data Source: HiPPIP (Novel)

		DNAH11	GGCT
Name		dynein axonemal heavy chain 11	gamma-glutamylcyclotransferase
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytoskeleton Microtubule Cilium Axoneme Dynein Complex Motile Cilium Cell Projection 9+0 Motile Cilium 9+2 Motile Cilium Proximal Portion Of Axoneme	Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Gamma-glutamylcyclotransferase Activity Lyase Activity Protein Homodimerization Activity
	Biological Process	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Regulation Of Cilium Beat Frequency Microtubule-based Movement Determination Of Left/right Symmetry Heart Development Learning Or Memory Flagellated Sperm Motility Determination Of Left/right Asymmetry In Nervous System Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cilium Movement Involved In Cell Motility Cardiac Septum Morphogenesis Protein Localization To Motile Cilium	Release Of Cytochrome C From Mitochondria
Pathways		None	Glutathione synthesis and recycling
Diseases		Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome	None
GWAS		Apolipoprotein B levels ( 32203549 ) Bipolar disorder ( 31043756 ) Bone mineral density (hip) ( 30172743 ) Brain morphology (MOSTest) ( 32665545 ) Breast cancer ( 29059683 ) Cholesterol, total ( 19060911 20686565 24097068 25961943 ) Cognitive decline (age-related) ( 24468470 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821 ) LDL cholesterol ( 19060911 30275531 20686565 25961943 24097068 ) LDL cholesterol levels ( 32203549 28334899 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Low density lipoprotein cholesterol levels ( 32154731 33339817 ) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolite levels ( 23823483 ) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227 ) Multiple myeloma ( 26007630 22120009 ) Multiple myeloma and monoclonal gammopathy ( 26007630 ) PR interval ( 32439900 ) Recurrent major depressive disorder x sex interaction ( 34099189 ) Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592 ) Serum total polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592 ) Subcortical volume (MOSTest) ( 32665545 ) Total cholesterol levels ( 30275531 33339817 28334899 ) Total ventricular volume ( 21116278 ) Whole-brain volume ( 21116278 )	No GWAS studies recorded
Novel Interactors		3 novel interactors: CPVL GGCT IL6	2 novel interactors: - DNAH11
Interacting Genes		None recorded	1 interacting genes: APP
Entrez ID		8701	79017
HPRD ID		09134	12912
Ensembl ID		ENSG00000105877	ENSG00000006625
Uniprot IDs		H9NAJ7 H9NAJ8 Q96DT5 Q96NT7	A0A090N7V5 O75223
PDB IDs		Not available	2I5T 2PN7 2Q53 2RBH 3CRY
GO Terms Enriched among Interactors		Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of MiRNA Processing Negative Regulation Of Primary MiRNA Processing Inflammatory Cell Apoptotic Process Glucagon Secretion Response To Peptidoglycan Vascular Endothelial Growth Factor Production Positive Regulation Of Apoptotic DNA Fragmentation Myeloid Cell Apoptotic Process Inflammatory Response To Wounding Hepatocyte Proliferation Negative Regulation Of Bone Resorption Interleukin-6 Receptor Complex Neutrophil Apoptotic Process Negative Regulation Of Bone Remodeling Germinal Center B Cell Differentiation Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Interleukin-21 Production Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Positive Regulation Of T-helper 2 Cell Cytokine Production Endocrine Pancreas Development Regulation Of Microglial Cell Activation Positive Regulation Of Extracellular Matrix Disassembly Interleukin-6 Receptor Binding Positive Regulation Of Platelet Aggregation T Follicular Helper Cell Differentiation Negative Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of Regulatory NcRNA Processing Negative Regulation Of Collagen Biosynthetic Process Regulation Of Astrocyte Activation Hepatic Immune Response Regulation Of Glucagon Secretion Negative Regulation Of MiRNA Processing Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Serine-type Carboxypeptidase Activity Gamma-glutamylcyclotransferase Activity Positive Regulation Of Type 2 Immune Response T-helper Cell Lineage Commitment CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Mediated Immunity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Glial Cell Proliferation Monocyte Chemotaxis Negative Regulation Of Lipid Storage	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Learning Or Memory Axon Midline Choice Point Recognition Microtubule-based Transport Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Determination Of Left/right Asymmetry In Nervous System Proximal Portion Of Axoneme Protein Localization To Motile Cilium 9+0 Motile Cilium Regulation Of Spontaneous Synaptic Transmission Cognition NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Microtubule-based Movement Antifungal Humoral Response Nuclear Envelope Lumen Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding