IL6 and PTHLH

Number of citations of the paper that reports this interaction (PMID 12000745)
4

Data Source:
HPRD (in vitro)

		IL6	PTHLH
Gene Name		interleukin 6	parathyroid hormone-like hormone
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Interleukin-6 Receptor Complex External Side Of Plasma Membrane	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Golgi Apparatus
	Molecular Function	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity	Hormone Activity Peptide Hormone Receptor Binding
	Biological Process	Neutrophil Apoptotic Process Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of Protein Kinase Activity Acute-phase Response Inflammatory Response Humoral Immune Response Aging Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Response To Heat Response To Cold Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Lipid Storage Response To Auditory Stimulus Cell Growth Cytokine-mediated Signaling Pathway Platelet Activation Response To Caffeine Endocrine Pancreas Development Neuron Projection Development Response To Nutrient Levels Response To Peptidoglycan Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Response To Insulin Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Import Into Nucleus, Translocation Positive Regulation Of T Cell Proliferation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Glucose Homeostasis Defense Response To Protozoan Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Amino Acid Positive Regulation Of MAPK Cascade Negative Regulation Of Chemokine Biosynthetic Process Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Nitric Oxide Biosynthetic Process Cell Redox Homeostasis Negative Regulation Of Fat Cell Differentiation Positive Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Translation Positive Regulation Of DNA Replication Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JAK-STAT Cascade Response To Antibiotic Muscle Cell Cellular Homeostasis Bone Remodeling Negative Regulation Of Hormone Secretion Negative Regulation Of Muscle Organ Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cytokine Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of Immunoglobulin Secretion Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Glucocorticoid Response To Calcium Ion Response To Electrical Stimulus Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Transmission Of Nerve Impulse Branching Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus T-helper 17 Cell Lineage Commitment Negative Regulation Of Neuron Death Positive Regulation Of STAT Protein Import Into Nucleus Positive Regulation Of Type B Pancreatic Cell Apoptotic Process	Skeletal System Development Endochondral Ossification Osteoblast Development Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Endoderm Development Female Pregnancy Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Epidermis Development Regulation Of Gene Expression Protein Processing Positive Regulation Of CAMP Biosynthetic Process Epithelial Cell Differentiation Negative Regulation Of Chondrocyte Differentiation Surfactant Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity CAMP Metabolic Process Lung Alveolus Development Mammary Gland Bud Elongation Nipple Sheath Formation
Pathways		Signaling by GPCR Signaling by FGFR in disease Cellular Senescence FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions TRIF-mediated TLR3/TLR4 signaling SHC-related events triggered by IGF1R ERK1 activation GRB2 events in EGFR signaling Senescence-Associated Secretory Phenotype (SASP) Signaling by ERBB4 ERK1 activation Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance ERK activation IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade Interleukin-6 signaling IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Activated TLR4 signalling MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade ERK2 activation Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades SHC1 events in EGFR signaling Toll Like Receptor 10 (TLR10) Cascade FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK2 activation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs		Ginseng
Diseases
GWAS		C-reactive protein ( 21196492) Dialysis-related mortality ( 21546767)	Breast cancer ( 23535729 23535733) Breast size ( 22747683)
Protein-Protein Interactions		5 interactors: IL6R IL6ST PTHLH SH3GL2 ZBTB16	6 interactors: ARRB1 CDK2 IL6 KLK3 KPNB1 PTH1R
Entrez ID		3569	5744
HPRD ID		00970	01348
Ensembl ID		ENSG00000136244	ENSG00000087494
Uniprot IDs		B4DNQ5 B4DVM1 B5MC21 P05231 Q75MH2	P12272 Q53XY9
PDB IDs		1ALU 1IL6 1N2Q 1P9M 2IL6	1BZG 1ET3 1M5N 3FFD 3H3G
Enriched GO Terms of Interacting Partners?		Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Ossification Interleukin-6-mediated Signaling Pathway Regulation Of Ossification Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Response To Interleukin-6 Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of Cell Proliferation Regulation Of Chondrocyte Differentiation Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Regulation Of JAK-STAT Cascade System Development Interleukin-11-mediated Signaling Pathway Nipple Sheath Formation Mammary Gland Bud Elongation Regulation Of Osteoblast Differentiation Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Cell Proliferation Hepatic Immune Response Interleukin-27-mediated Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Differentiation Positive Regulation Of Immune System Process Negative Regulation Of Interleukin-6-mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Developmental Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of NK T Cell Differentiation Mammary Gland Bud Morphogenesis Positive Regulation Of Cell-cell Adhesion Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of Activation Of Janus Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Immune System Process Positive Regulation Of Cell Activation Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Negative Regulation Of Multicellular Organismal Metabolic Process Cell Differentiation	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Positive Regulation Of Acute Inflammatory Response Bone Remodeling Regulation Of Protein Processing Positive Regulation Of DNA Replication Regulation Of Acute Inflammatory Response Acute Inflammatory Response Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Inflammatory Response Glucagon Secretion Cellular Response To Reactive Oxygen Species Positive Regulation Of Cellular Biosynthetic Process Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Tissue Remodeling Regulation Of DNA Replication Positive Regulation Of ERK1 And ERK2 Cascade Factor XII Activation Hepatic Immune Response Positive Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Metabolic Process T-helper 17 Cell Lineage Commitment Negative Regulation Of Chemokine Biosynthetic Process Neutrophil Apoptotic Process Positive Regulation Of Cell Proliferation Cellular Macromolecule Catabolic Process Regulation Of Protein Metabolic Process Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of DNA-dependent DNA Replication Initiation Positive Regulation Of STAT Protein Import Into Nucleus Positive Regulation Of Fibrinolysis Platelet Activation Positive Regulation Of Protein Secretion Response To Reactive Oxygen Species Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Negative Regulation Of Cytokine Production Regulation Of Cysteine-type Endopeptidase Activity T-helper 17 Cell Differentiation Apoptotic Process Regulation Of Angiogenesis Programmed Cell Death
Tagcloud ?		adapted antisera biosensors biotinylated catalyzes coated colored colorless conjugated densitometry easily electrophoretic ideal immunosorbent interfere lends manipulation oligonucleotides optical peroxidase plate plates reader readily recognised robotic shift streptavidin throughput	2p11 3p13 assigned atrophy cd4 chromosomal chromosome del deletion dentatorubral drpla f8vwf genotypes hormone localization loci mapped mapping p11 p12 p13 p55 pallidoluysian parathyroid parents precise segregation von willebrand
Tagcloud (Difference) ?		adapted antisera biosensors biotinylated catalyzes coated colored colorless conjugated densitometry easily electrophoretic ideal immunosorbent interfere lends manipulation oligonucleotides optical peroxidase plate plates reader readily recognised robotic shift streptavidin throughput	2p11 3p13 assigned atrophy cd4 chromosomal chromosome del deletion dentatorubral drpla f8vwf genotypes hormone localization loci mapped mapping p11 p12 p13 p55 pallidoluysian parathyroid parents precise segregation von willebrand
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