DNAH11

Name	dynein axonemal heavy chain 11
Structure	No pdb structure
Novel Interactors	3 novel interactors: CPVL GGCT IL6
Interactors	None recorded
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytoskeleton Microtubule Cilium Axoneme Dynein Complex Motile Cilium Cell Projection 9+0 Motile Cilium 9+2 Motile Cilium Proximal Portion Of Axoneme
	Molecular Function	Nucleotide Binding ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Cilium Movement Epithelial Cilium Movement Involved In Extracellular Fluid Movement Regulation Of Cilium Beat Frequency Microtubule-based Movement Determination Of Left/right Symmetry Heart Development Learning Or Memory Flagellated Sperm Motility Determination Of Left/right Asymmetry In Nervous System Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Cilium Movement Involved In Cell Motility Cardiac Septum Morphogenesis Protein Localization To Motile Cilium
Diseases	Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
GWAS	Apolipoprotein B levels ( 32203549 ) Bipolar disorder ( 31043756 ) Bone mineral density (hip) ( 30172743 ) Brain morphology (MOSTest) ( 32665545 ) Breast cancer ( 29059683 ) Cholesterol, total ( 19060911 20686565 24097068 25961943 ) Cognitive decline (age-related) ( 24468470 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Gut microbiota relative abundance (unclassified genus belonging to family Clostridiaceae) ( 33208821 ) LDL cholesterol ( 19060911 30275531 20686565 25961943 24097068 ) LDL cholesterol levels ( 32203549 28334899 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Low density lipoprotein cholesterol levels ( 32154731 33339817 ) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolite levels ( 23823483 ) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227 ) Multiple myeloma ( 26007630 22120009 ) Multiple myeloma and monoclonal gammopathy ( 26007630 ) PR interval ( 32439900 ) Recurrent major depressive disorder x sex interaction ( 34099189 ) Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592 ) Serum total polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592 ) Subcortical volume (MOSTest) ( 32665545 ) Total cholesterol levels ( 30275531 33339817 28334899 ) Total ventricular volume ( 21116278 ) Whole-brain volume ( 21116278 )
Entrez ID	8701
HPRD ID	09134
Ensembl ID	ENSG00000105877
Uniprot IDs	H9NAJ7 H9NAJ8 Q96DT5 Q96NT7
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of MiRNA Processing Negative Regulation Of Primary MiRNA Processing Inflammatory Cell Apoptotic Process Glucagon Secretion Response To Peptidoglycan Vascular Endothelial Growth Factor Production Positive Regulation Of Apoptotic DNA Fragmentation Myeloid Cell Apoptotic Process Inflammatory Response To Wounding Hepatocyte Proliferation Negative Regulation Of Bone Resorption Interleukin-6 Receptor Complex Neutrophil Apoptotic Process Negative Regulation Of Bone Remodeling Germinal Center B Cell Differentiation Positive Regulation Of Type B Pancreatic Cell Apoptotic Process Positive Regulation Of Interleukin-21 Production Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Positive Regulation Of T-helper 2 Cell Cytokine Production Endocrine Pancreas Development Regulation Of Microglial Cell Activation Positive Regulation Of Extracellular Matrix Disassembly Interleukin-6 Receptor Binding Positive Regulation Of Platelet Aggregation T Follicular Helper Cell Differentiation Negative Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of Regulatory NcRNA Processing Negative Regulation Of Collagen Biosynthetic Process Regulation Of Astrocyte Activation Hepatic Immune Response Regulation Of Glucagon Secretion Negative Regulation Of MiRNA Processing Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Serine-type Carboxypeptidase Activity Gamma-glutamylcyclotransferase Activity Positive Regulation Of Type 2 Immune Response T-helper Cell Lineage Commitment CD4-positive, Alpha-beta T Cell Lineage Commitment Positive Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Neutrophil Mediated Immunity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Glial Cell Proliferation Monocyte Chemotaxis Negative Regulation Of Lipid Storage