GNG10 and GNB2

Number of citations of the paper that reports this interaction (PMID 7665596)
18

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		GNG10	GNB2
Gene Name		guanine nucleotide binding protein (G protein), gamma 10	guanine nucleotide binding protein (G protein), beta polypeptide 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Extracellular Vesicular Exosome	Extracellular Space Lysosomal Membrane Plasma Membrane Focal Adhesion Membrane Vesicle Protein Complex Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Signal Transducer Activity	GTPase Activity Signal Transducer Activity Calcium Channel Regulator Activity Protein Binding Protein Complex Binding GTPase Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: GNB1 GNB2 GNB3 GNB4 KRT31 KRT38 TCF4	31 interactors: ANXA7 ATXN10 CAPNS1 CDKN1A CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 GSK3B ID3 NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1
Entrez ID		2790	2783
HPRD ID		10374	11820
Ensembl ID		ENSG00000242616	ENSG00000172354
Uniprot IDs		P50151	P62879 Q6FHM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Energy Reserve Metabolic Process Cellular Response To Glucagon Stimulus Response To Glucagon Energy Derivation By Oxidation Of Organic Compounds Generation Of Precursor Metabolites And Energy Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Oxidation-reduction Process Response To Organonitrogen Compound Response To Hormone Response To Organic Substance Synaptic Transmission Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Cellular Response To Organic Substance Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Maintenance Of DNA Repeat Elements Cell-cell Signaling Small Molecule Metabolic Process Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Genitalia Morphogenesis Cardiac Muscle Cell Apoptotic Process Myoblast Fate Commitment Muscle Cell Apoptotic Process G-protein Coupled Receptor Signaling Pathway Secretory Granule Localization Signal Transduction Hindgut Morphogenesis Insulin Metabolic Process Hindgut Development Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Protein Export From Nucleus G-protein Coupled Acetylcholine Receptor Signaling Pathway Positive Regulation Of Glycoprotein Biosynthetic Process Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Triglyceride Biosynthetic Process Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell Communication Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Gluconeogenesis Regulation Of Triglyceride Biosynthetic Process Genitalia Morphogenesis Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E	Cellular Response To Glucagon Stimulus Response To Glucagon Synaptic Transmission Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Peptide Hormone Cellular Response To Peptide Response To Peptide Cell-cell Signaling Response To Hormone Cellular Response To Hormone Stimulus Generation Of Precursor Metabolites And Energy Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signal Transduction Response To Organic Substance G-protein Coupled Receptor Signaling Pathway Signaling Cellular Response To Organic Substance Cell Communication Cellular Response To Stimulus Response To Stimulus Regulation Of Cellular Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of Signal Transduction Cell Cycle Regulation Of CAMP Biosynthetic Process Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Hemostasis Positive Regulation Of Signal Transduction Response To Wounding Positive Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Response To Stress Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?			abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb1 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Difference) ?			abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb1 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Intersection) ?