EIF3I and NEDD8

Number of citations of the paper that reports this interaction (PubMedID 34642328)
74

Data Source:
BioGRID (pull down)

		EIF3I	NEDD8
Description		eukaryotic translation initiation factor 3 subunit I	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	Protein Binding Protein Tag Activity Ubiquitin Protein Ligase Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation	Regulation Of Transcription By RNA Polymerase II Proteolysis Ubiquitin-dependent Protein Catabolic Process Intracellular Protein Localization Anatomical Structure Morphogenesis Protein Ubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Protein Modification Process Protein Neddylation Cellular Response To Camptothecin Regulation Of Postsynapse Assembly
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases
GWAS			Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		14 interacting genes: EIF3A EIF3B EIF4G1 ERCC6 ESR1 EXOSC6 LIG4 METTL3 NEDD8 PAXIP1 SUMO4 TGFB1 TGFBR2 UBC	71 interacting genes: AHR ANKRD13D ARIH2 ATXN3 BAG3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNAJA2 DNAJB2 DNMT3B EIF3I FAF1 GARS1 GHR GRN GTF3C3 HDAC6 HGS HIF1A HSPA1B HSPA4 HSPA4L HSPA8 HSPA9 HSPH1 HYPK KLHDC2 N4BP1 NAE1 NSFL1C NUB1 NXPH2 OLFML2B OTUB1 OTUB2 OTUD5 OTUD6B PARP1 PCNA POLI PPP1CA PRKN PSMA6 PSMD4 PTK2 RAD23A SENP8 SET SIRT1 SMURF1 SQSTM1 TOLLIP TP53 TUBB4B UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		8668	4738
HPRD ID		04884	04412
Ensembl ID		ENSG00000084623	ENSG00000129559
Uniprot IDs		A0A7I2YQI2 Q13347 Q5U0F4	Q15843
PDB IDs		6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8XXN 9BLN	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU 7B5L 7B5N 7ONI 8B3G 8B3I 8CAF 8H38 8Q7H 8RX0 8WQC 8WQG 8WZN 8WZO
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Positive Regulation Of DNA Recombination Cytoplasmic Translational Initiation Regulation Of DNA Recombination Response To Ionizing Radiation Regulation Of Isotype Switching Positive Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Type III Transforming Growth Factor Beta Receptor Binding Langerhans Cell Differentiation Viral Translational Termination-reinitiation Translation Initiation Factor Activity Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Immunoglobulin Production Vasculogenesis Connective Tissue Development Response To Radiation Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Type I Transforming Growth Factor Beta Receptor Binding IRES-dependent Viral Translational Initiation Regulation Of Immunoglobulin Production Translational Initiation Branch Elongation Of An Epithelium Respiratory Tube Development Positive Regulation Of B Cell Activation Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Fibroblast Proliferation Regulation Of Lymphocyte Activation Eukaryotic Translation Initiation Factor 3 Complex Regulation Of Gene Expression Eukaryotic 48S Preinitiation Complex Positive Regulation Of DNA Metabolic Process Eukaryotic 43S Preinitiation Complex Regulation Of Translational Initiation Regulation Of Macromolecule Biosynthetic Process Axis Elongation Branching Involved In Mammary Gland Duct Morphogenesis Neurogenesis Macromolecule Biosynthetic Process Myeloid Dendritic Cell Differentiation Translation Initiation Factor Binding Regulation Of Protein Metabolic Process Branching Morphogenesis Of An Epithelial Tube Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Lymphocyte Mediated Immunity	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Protein Catabolic Process Protein Metabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin Protein Ligase Binding Proteasomal Protein Catabolic Process Ubiquitin Binding Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Cytosol Positive Regulation Of Catabolic Process Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Nucleoplasm Regulation Of Post-translational Protein Modification Regulation Of Proteolysis Protein Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Deubiquitination Regulation Of Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Nucleus Protein Polyubiquitination Protein Targeting To Vacuole Involved In Autophagy Cullin-RING Ubiquitin Ligase Complex DeNEDDylase Activity Aggresome ATP-dependent Protein Folding Chaperone Polyubiquitin Modification-dependent Protein Binding Regulation Of Proteasomal Protein Catabolic Process Protein Folding Response To Stress Protein Neddylation Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Stability Positive Regulation Of Metabolic Process Cellular Response To Stress Cytoplasm
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