EIF3I and METTL3

Number of citations of the paper that reports this interaction (PubMedID 30232453)
28

Data Source:
BioGRID (pull down)

		EIF3I	METTL3
Description		eukaryotic translation initiation factor 3 subunit I	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex Oxidoreductase Complex
	Molecular Function	RNA Binding Translation Initiation Factor Activity Protein Binding	MRNA M(6)A Methyltransferase Activity RNA Binding MRNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity Transferase Activity Protein Heterodimerization Activity S-adenosyl-L-methionine Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation	MRNA Splicing, Via Spliceosome RNA Methylation Immune System Process MRNA Processing MRNA Export From Nucleus DNA Damage Response Spermatogenesis Circadian Rhythm Dosage Compensation By Inactivation Of X Chromosome MRNA Modification Stem Cell Population Maintenance Forebrain Radial Glial Cell Differentiation Cell Differentiation Primary MiRNA Processing Methylation Cellular Response To UV Gliogenesis Innate Immune Response Regulation Of T Cell Differentiation Positive Regulation Of Translation Negative Regulation Of Notch Signaling Pathway Oogenesis Rhythmic Process Regulation Of Meiotic Cell Cycle Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Endothelial To Hematopoietic Transition Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Cap-independent Translational Initiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS			Response to Homoharringtonine (cytotoxicity) ( 25628645)
Interacting Genes		14 interacting genes: EIF3A EIF3B EIF4G1 ERCC6 ESR1 EXOSC6 LIG4 METTL3 NEDD8 PAXIP1 SUMO4 TGFB1 TGFBR2 UBC	9 interacting genes: EIF3G EIF3I EIF3J EIF3M MAPK1 MAPK14 MAPK8 MTDH USP5
Entrez ID		8668	56339
HPRD ID		04884	14389
Ensembl ID		ENSG00000084623	ENSG00000165819
Uniprot IDs		A0A7I2YQI2 Q13347 Q5U0F4	Q86U44
PDB IDs		6YBT 6ZMW 6ZON 6ZP4 6ZVJ 7A09 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8XXN 9BLN	5IL0 5IL1 5IL2 5K7M 5K7U 5K7W 5L6D 5L6E 5TEY 5YZ9 6TTP 6TTT 6TTV 6TTW 6TTX 6TU1 6Y4G 7ACD 7NHG 7NHH 7NHI 7NHJ 7NHV 7NI7 7NI8 7NI9 7NIA 7NID 7O08 7O09 7O0L 7O0M 7O0P 7O0Q 7O0R 7O27 7O28 7O29 7O2E 7O2F 7O2H 7O2I 7O2X 7OED 7OEE 7OEF 7OEG 7OEH 7OEI 7OEJ 7OEK 7OEL 7OEM 7OQL 7OQO 7OQP 7RX6 7RX7 7RX8 8BN8 8PW8 8PW9 8PWA 8PWB 9G4S 9G4U 9G4W
Enriched GO Terms of Interacting Partners?		Protein Tag Activity Positive Regulation Of DNA Recombination Cytoplasmic Translational Initiation Regulation Of DNA Recombination Response To Ionizing Radiation Regulation Of Isotype Switching Positive Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Type III Transforming Growth Factor Beta Receptor Binding Langerhans Cell Differentiation Viral Translational Termination-reinitiation Translation Initiation Factor Activity Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Macromolecule Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Immunoglobulin Production Vasculogenesis Connective Tissue Development Response To Radiation Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Type I Transforming Growth Factor Beta Receptor Binding IRES-dependent Viral Translational Initiation Regulation Of Immunoglobulin Production Translational Initiation Branch Elongation Of An Epithelium Respiratory Tube Development Positive Regulation Of B Cell Activation Formation Of Cytoplasmic Translation Initiation Complex Regulation Of Fibroblast Proliferation Regulation Of Lymphocyte Activation Eukaryotic Translation Initiation Factor 3 Complex Regulation Of Gene Expression Eukaryotic 48S Preinitiation Complex Positive Regulation Of DNA Metabolic Process Eukaryotic 43S Preinitiation Complex Regulation Of Translational Initiation Regulation Of Macromolecule Biosynthetic Process Axis Elongation Branching Involved In Mammary Gland Duct Morphogenesis Neurogenesis Macromolecule Biosynthetic Process Myeloid Dendritic Cell Differentiation Translation Initiation Factor Binding Regulation Of Protein Metabolic Process Branching Morphogenesis Of An Epithelial Tube Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Lymphocyte Mediated Immunity	Formation Of Cytoplasmic Translation Initiation Complex Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Cytoplasmic Translational Initiation Translation Initiation Factor Activity MAP Kinase Activity Translational Initiation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Lipopolysaccharide-mediated Signaling Pathway Protein-RNA Complex Assembly Protein Metabolic Process Eukaryotic Translation Initiation Factor 3 Complex, EIF3m Protein-containing Complex Assembly Protein-containing Complex Organization Translation Positive Regulation Of Cyclase Activity Peptidyl-threonine Phosphorylation Canonical Inflammasome Complex Assembly MAPK Cascade Macromolecule Metabolic Process Cytoplasm Macromolecule Biosynthetic Process Cellular Component Assembly Response To Lipopolysaccharide Cellular Senescence Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation JUN Phosphorylation Response To Molecule Of Bacterial Origin Cytosol Energy Homeostasis Protein Serine Kinase Activity Regulation Of Immune Response Protein Serine/threonine Kinase Activity Protein Phosphatase Binding Cytosine Metabolic Process Cellular Response To Tumor Necrosis Factor Regulation Of Synaptic Membrane Adhesion Interleukin-34-mediated Signaling Pathway JUN Kinase Activity Regulation Protein Catabolic Process At Presynapse Regulation Of Ossification Response To Nutrient Levels Ficolin-1-rich Granule Lumen Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Protein Kinase Activity Regulation Of Golgi Inheritance
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