MYDGF and HPCA

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MYDGF	HPCA
Name		myeloid derived growth factor	hippocalcin
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus	Cytoplasm Cytosol Membrane Axon Dendrite Membrane Neuronal Cell Body Membrane Dendrite Cytoplasm Perikaryon Dendritic Spine Head Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Actin Binding Calcium Ion Binding Protein Binding Kinase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Regulation Of Signal Transduction Calcium-mediated Signaling Inner Ear Development Retina Development In Camera-type Eye Cellular Response To Electrical Stimulus Cellular Response To Calcium Ion Positive Regulation Of Protein Targeting To Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Voltage-gated Calcium Channel Activity Response To Ketamine Response To L-glutamate Response To Aroclor 1254 Cellular Response To L-glutamate
Pathways		XBP1(S) activates chaperone genes	None
GWAS		No GWAS studies recorded	Daytime nap ( 33568662 )
Interacting Genes		13 interacting genes: ACOT13 BAG6 EIF3F HPCA HPCAL1 LCN2 MDM2 NCALD SGTA SGTB UBQLN1 UBQLN2 UBQLN4	17 interacting genes: AP2B1 C1QTNF2 CKMT1A CKMT1B CREM DTX2 GATA5 IL36RN MLLT10 MYDGF NAIP NMT1 PRR35 SLC16A3 TEPSIN UQCRB VWC2
Entrez ID		56005	3208
HPRD ID		08415	00811
Ensembl ID		ENSG00000074842	ENSG00000121905
Uniprot IDs		Q969H8	P84074
PDB IDs		6O6W 6SVK 6SVL	5G4P 5G58 5M6C 7OWM
GO Terms Enriched among Interactors		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Identical Protein Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Cellular Response To Stress Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Protein Targeting To Membrane Regulation Of Receptor Internalization Response To Endoplasmic Reticulum Stress Autophagosome Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Stress Macromolecule Catabolic Process Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Receptor-mediated Endocytosis Cellular Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Cellular Response To Decreased Oxygen Levels Negative Regulation Of Proteolysis Cellular Response To Oxygen Levels Positive Regulation Of Protein Metabolic Process Protein Insertion Into ER Membrane Response To Iron Ion Molecular Adaptor Activity Regulation Of Macroautophagy Protein Targeting Establishment Of Protein Localization To Membrane Regulation Of Protein Metabolic Process Hsp70 Protein Binding	Phosphocreatine Biosynthetic Process Creatine Kinase Activity