MYDGF and ACOT13

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		MYDGF	ACOT13
Name		myeloid derived growth factor	acyl-CoA thioesterase 13
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Spindle Cytosol Cytoskeleton
	Molecular Function	Protein Binding	Protein Binding Hydrolase Activity Metal Ion Binding Fatty Acyl-CoA Hydrolase Activity
	Biological Process	Angiogenesis Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Lipid Metabolic Process Protein Homotetramerization Negative Regulation Of Cold-induced Thermogenesis
Pathways		XBP1(S) activates chaperone genes	Mitochondrial Fatty Acid Beta-Oxidation
Drugs		None	2-Undecanone
GWAS		No GWAS studies recorded	Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444 )
Interacting Genes		13 interacting genes: ACOT13 BAG6 EIF3F HPCA HPCAL1 LCN2 MDM2 NCALD SGTA SGTB UBQLN1 UBQLN2 UBQLN4	4 interacting genes: MYDGF NTAQ1 RBBP6 SPG21
Entrez ID		56005	55856
HPRD ID		08415	07158
Ensembl ID		ENSG00000074842	ENSG00000112304
Uniprot IDs		Q969H8	Q9NPJ3
PDB IDs		6O6W 6SVK 6SVL	2F0X 2H4U 3F5O
GO Terms Enriched among Interactors		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Identical Protein Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Cellular Response To Stress Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Protein Targeting To Membrane Regulation Of Receptor Internalization Response To Endoplasmic Reticulum Stress Autophagosome Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Cellular Response To Stress Macromolecule Catabolic Process Protein Catabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Receptor-mediated Endocytosis Cellular Response To Hypoxia Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Cellular Response To Decreased Oxygen Levels Negative Regulation Of Proteolysis Cellular Response To Oxygen Levels Positive Regulation Of Protein Metabolic Process Protein Insertion Into ER Membrane Response To Iron Ion Molecular Adaptor Activity Regulation Of Macroautophagy Protein Targeting Establishment Of Protein Localization To Membrane Regulation Of Protein Metabolic Process Hsp70 Protein Binding	Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity