ABCB11 and HAX1

Number of citations of the paper that reports this interaction (PubMedID 15159385)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ABCB11	HAX1
Description		ATP binding cassette subfamily B member 11	HCLS1 associated protein X-1
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Apical Part Of Cell Intercellular Canaliculus Intracellular Canaliculus Recycling Endosome Recycling Endosome Membrane Extracellular Exosome	P-body Nucleus Nuclear Envelope Transcription Regulator Complex Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Endoplasmic Reticulum Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Bile Acid Transmembrane Transporter Activity Canalicular Bile Acid Transmembrane Transporter Activity ABC-type Bile Acid Transporter Activity ATP Hydrolysis Activity ABC-type Transporter Activity	Protein Binding Protein Domain Specific Binding Interleukin-1 Binding Signaling Adaptor Activity
	Biological Process	Fatty Acid Metabolic Process Bile Acid Biosynthetic Process Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Protein Ubiquitination Regulation Of Fatty Acid Beta-oxidation Cholesterol Homeostasis Xenobiotic Export From Cell Transmembrane Transport Lipid Homeostasis Phospholipid Homeostasis Positive Regulation Of Bile Acid Secretion Regulation Of Bile Acid Metabolic Process	Mitochondrion Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Regulation Of Actin Filament Organization Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion
Pathways		Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective ABCB11 causes PFIC2 and BRIC2
Drugs		ATP Glyburide
Diseases		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)	Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 29403010 33339817) Cholesterol, total ( 24097068) Egg allergy ( 25710614) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 18521185) Fructosamine levels ( 34753797) Gamma glutamyl transferase levels ( 33339817 29403010) Glycated hemoglobin levels ( 29170429 24647736 34059833 20858683 31213470) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolically unhealthy in normal weight ( 33500527) Metabolite levels ( 21909109) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure in sickle cell anemia ( 24058526) Total cholesterol levels ( 30275531 28334899)	Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Mean spheric corpuscular volume ( 32888494) Nicotine dependence ( 28440896) Non-albumin protein levels ( 29403010) Reticulocyte count ( 32888494) Serum total protein levels ( 29403010) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549)
Interacting Genes		4 interacting genes: DDIT4L HAX1 LY6D NR4A1	26 interacting genes: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D POLR1H PPP3CC PRNP RBX1 RNF217 RPA1 STAT5B SVIL WEE2-AS1 YWHAQ ZNF420
Entrez ID		8647	10456
HPRD ID		04436	12075
Ensembl ID		ENSG00000073734	ENSG00000143575
Uniprot IDs		O95342	A0A0S2Z565 A0A0S2Z591 O00165
PDB IDs		6LR0 7DV5 7E1A 8PM6 8PMD 8PMJ
Enriched GO Terms of Interacting Partners?			Ceramide Floppase Activity Ceramide Translocation Cytosol Regulation Of Transport Sphingolipid Translocation Phosphatidylcholine Floppase Activity ABC-type Transporter Activity Intercellular Canaliculus Regulation Of Monoatomic Ion Transport Regulation Of Calcium Ion Import Transmembrane Transporter Binding Dendritic Spine Maintenance ATPase-coupled Intramembrane Lipid Transporter Activity Regulation Of Interleukin-2 Production Homeostatic Process Xenobiotic Export From Cell ABC-type Xenobiotic Transporter Activity Regulation Of Calcium Ion Import Across Plasma Membrane RNA Polymerase I Complex Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Transport Ceramide Transport Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Cytoplasm Negative Regulation Of Monoatomic Ion Transport Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Dendritic Spine Organization Response To Copper Ion Multicellular Organismal-level Homeostasis Positive Regulation Of Interleukin-2 Production Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Phospholipid Translocation ATPase-coupled Transmembrane Transporter Activity Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier Metanephric Cortical Collecting Duct Development Metanephric Cortex Development Metanephric Distal Tubule Development Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Transmembrane Transport Type 8 Metabotropic Glutamate Receptor Binding
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