ABCB11 and HAX1

Number of citations of the paper that reports this interaction (PMID 15159385)
11

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		ABCB11	HAX1
Gene Name		ATP-binding cassette, sub-family B (MDR/TAP), member 11	HCLS1 associated protein X-1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Apical Part Of Cell Intercellular Canaliculus Extracellular Vesicular Exosome	Nuclear Envelope Transcription Factor Complex Mitochondrion Endoplasmic Reticulum Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane
	Molecular Function	Transporter Activity ATP Binding Sodium-exporting ATPase Activity, Phosphorylative Mechanism Canalicular Bile Acid Transmembrane Transporter Activity Bile Acid-exporting ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances	Protein Binding Protein Domain Specific Binding Interleukin-1 Binding Protein N-terminus Binding
	Biological Process	Bile Acid Biosynthetic Process Transport Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Sodium Ion Transmembrane Transport Small Molecule Metabolic Process Transmembrane Transport	Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Mitochondrion Degradation Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		Bile acid and bile salt metabolism Metabolism of lipids and lipoproteins Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Recycling of bile acids and salts Synthesis of bile acids and bile salts
Drugs		Adenosine triphosphate Glyburide
Diseases
GWAS		Fasting plasma glucose ( 18521185) Glycated hemoglobin levels ( 20858683) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolite levels ( 21909109)
Protein-Protein Interactions		3 interactors: HAX1 LY6D NR4A1	23 interactors: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D PPP3CC RBX1 RPA1 STAT5B SVIL YWHAQ ZNF420 ZNRD1
Entrez ID		8647	10456
HPRD ID		04436	12075
Ensembl ID		ENSG00000073734	ENSG00000143575
Uniprot IDs		O95342	O00165
PDB IDs
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Organelle Organization Positive Regulation Of Interleukin-2 Production Xenobiotic Transport Response To Abiotic Stimulus Positive Regulation Of Transport DNA-templated Transcription, Initiation Regulation Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cellular Localization Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Positive Regulation Of Cytokine Production Regulation Of Establishment Of Protein Localization Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Drug Transmembrane Transport Positive Regulation Of Cation Channel Activity Transcription From RNA Polymerase I Promoter Immune System Process Response To Stress Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Transporter Activity Acute-phase Response Regulation Of Intracellular Transport Positive Regulation Of Innate Immune Response Actin Filament Polymerization Protein Monoubiquitination Positive Regulation Of Intracellular Signal Transduction Drug Transport Signal Transduction Negative Regulation Of Ion Transmembrane Transport Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ion Transmembrane Transporter Activity Metanephric Cortex Development Metanephric Cortical Collecting Duct Development JAK-STAT Cascade
Tagcloud ?		1b1 3a4 abcc2 abcg2 ambrisentan bosentan calcein cyp2c19 cyp3a4 desmethyl endothelin fluorescein geometric gp hek hydroxy hydroxylated hydroxymethyl ls180 mdr1 oatp oatp1b1 oatp1b3 p450 perpetrators pharmacokinetic pregnane transporting	1222a abolishing aciduria arg408gly atp2a2 atrophy biochemically caseinolytic cataracts cerebellar clpb congenital deleterious disability encephalopathy exome intellectual kostmann methylglutaconic movement neutropenia nonprogressive overlapping peptidase prenatal sanger scn unrelated zebrafish
Tagcloud (Difference) ?		1b1 3a4 abcc2 abcg2 ambrisentan bosentan calcein cyp2c19 cyp3a4 desmethyl endothelin fluorescein geometric gp hek hydroxy hydroxylated hydroxymethyl ls180 mdr1 oatp oatp1b1 oatp1b3 p450 perpetrators pharmacokinetic pregnane transporting	1222a abolishing aciduria arg408gly atp2a2 atrophy biochemically caseinolytic cataracts cerebellar clpb congenital deleterious disability encephalopathy exome intellectual kostmann methylglutaconic movement neutropenia nonprogressive overlapping peptidase prenatal sanger scn unrelated zebrafish
Tagcloud (Intersection) ?