ABCB11 and LY6D

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ABCB11	LY6D
Description		ATP binding cassette subfamily B member 11	lymphocyte antigen 6 family member D
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Apical Part Of Cell Intercellular Canaliculus Intracellular Canaliculus Recycling Endosome Recycling Endosome Membrane Extracellular Exosome	Extracellular Region Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Bile Acid Transmembrane Transporter Activity Canalicular Bile Acid Transmembrane Transporter Activity ABC-type Bile Acid Transporter Activity ATP Hydrolysis Activity ABC-type Transporter Activity	Protein Binding
	Biological Process	Fatty Acid Metabolic Process Bile Acid Biosynthetic Process Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Bile Acid Metabolic Process Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Protein Ubiquitination Regulation Of Fatty Acid Beta-oxidation Cholesterol Homeostasis Xenobiotic Export From Cell Transmembrane Transport Lipid Homeostasis Phospholipid Homeostasis Positive Regulation Of Bile Acid Secretion Regulation Of Bile Acid Metabolic Process	Cell Adhesion Lymphocyte Differentiation Response To Stilbenoid
Pathways		Recycling of bile acids and salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective ABCB11 causes PFIC2 and BRIC2	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		ATP Glyburide
Diseases		Familial cholestasis, including: Progressive familial intrahepatic cholestasis (PFIC); Benign recurrent intrahepatic cholestasis (BRIC); Intrahepatic cholestasis of pregnancy (ICP); North American Indian childhood cirrhosis (NAIC)
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 29403010 33339817) Cholesterol, total ( 24097068) Egg allergy ( 25710614) Fasting blood glucose ( 29621232) Fasting plasma glucose ( 18521185) Fructosamine levels ( 34753797) Gamma glutamyl transferase levels ( 33339817 29403010) Glycated hemoglobin levels ( 29170429 24647736 34059833 20858683 31213470) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic traits ( 19060910) Metabolically unhealthy in normal weight ( 33500527) Metabolite levels ( 21909109) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure in sickle cell anemia ( 24058526) Total cholesterol levels ( 30275531 28334899)
Interacting Genes		4 interacting genes: DDIT4L HAX1 LY6D NR4A1	7 interacting genes: ABCB11 AQP6 ARFIP2 ELOVL4 PKIB TMEM31 TMEM86B
Entrez ID		8647	8581
HPRD ID		04436	09370
Ensembl ID		ENSG00000073734	ENSG00000167656
Uniprot IDs		O95342	Q14210
PDB IDs		6LR0 7DV5 7E1A 8PM6 8PMD 8PMJ
Enriched GO Terms of Interacting Partners?			PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Canalicular Bile Acid Transmembrane Transporter Activity Positive Regulation Of Bile Acid Secretion Canalicular Bile Acid Transport D-lysine 5,6-aminomutase Activity Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity Intracellular Canaliculus Regulation Of Bile Acid Secretion ABC-type Bile Acid Transporter Activity Membrane Curvature Sensor Activity Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Intercellular Canaliculus Monoatomic Anion Channel Activity Renal Water Transport Fatty Acid Elongation, Saturated Fatty Acid Ammonium Transmembrane Transport Ammonium Channel Activity CAMP-dependent Protein Kinase Inhibitor Activity Carboxylic Acid Biosynthetic Process G Protein-coupled Photoreceptor Activity Bile Acid Transmembrane Transporter Activity Regulation Of Bile Acid Metabolic Process Water Channel Activity Carbon Dioxide Transport Very Long-chain Fatty Acid Biosynthetic Process Fatty Acid Elongation Fatty Acid Metabolic Process Xenobiotic Export From Cell ABC-type Xenobiotic Transporter Activity Xenobiotic Transmembrane Transport Phosphatidylcholine Acyl-chain Remodeling Phospholipid Homeostasis Regulation Of Fatty Acid Beta-oxidation Protein Localization To Phagophore Assembly Site Lipid Metabolic Process Long-chain Fatty-acyl-CoA Biosynthetic Process Bile Acid And Bile Salt Transport GTP-dependent Protein Binding Ether Lipid Metabolic Process
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