RUNX3 and CBFB

Number of citations of the paper that reports this interaction (PMID 7622058)
34

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RUNX3	CBFB
Gene Name		runt-related transcription factor 3	core-binding factor, beta subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleolus Cytoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle	Nucleus Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding ATP Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chondrocyte Differentiation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Phosphorylation Axon Guidance Hair Follicle Morphogenesis Interferon-gamma Production Negative Regulation Of Cell Cycle Cell Maturation Peripheral Nervous System Neuron Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Lymphocyte Differentiation Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Definitive Hemopoiesis
Pathways
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469) Celiac disease ( 20190752) Crohn's disease ( 23266558)
Protein-Protein Interactions		13 interactors: CBFB EP300 HDAC1 HDAC2 HDAC4 HDAC5 NOTCH1 SMAD3 SMURF1 SMURF2 SP110 TLE1 YAP1	9 interactors: CBFA2T2 CHGB COPRS CUL5 RAB2A RNF7 RUNX1 RUNX2 RUNX3
Entrez ID		864	865
HPRD ID		02565	00418
Ensembl ID		ENSG00000020633	ENSG00000067955
Uniprot IDs		Q13761	Q13951
PDB IDs			1CL3 1E50 1H9D
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Histone H4 Deacetylation Regulation Of Transcription, DNA-templated Negative Regulation Of Ossification Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Gene Expression Histone H3 Deacetylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Histone H3-K9 Modification Regulation Of Striated Muscle Tissue Development Negative Regulation Of Osteoblast Differentiation Regulation Of Wnt Signaling Pathway Negative Regulation Of Cellular Metabolic Process Notch Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Signal Transduction Histone Deacetylation Transcription Initiation From RNA Polymerase II Promoter Protein Deacetylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Myotube Differentiation Chromatin Remodeling Negative Regulation Of Signaling Regulation Of Ossification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression, Epigenetic Regulation Of Canonical Wnt Signaling Pathway Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter	Peripheral Nervous System Neuron Development Hair Follicle Morphogenesis Epidermis Morphogenesis Skin Morphogenesis Chondrocyte Differentiation Hair Follicle Development Hair Cycle Process Hair Cycle Peripheral Nervous System Development Skeletal System Development Positive Regulation Of Progesterone Secretion Regulation Of Cell Proliferation Regulation Of Progesterone Secretion Cell Maturation Regulation Of Hair Follicle Cell Proliferation Tissue Development Intrinsic Apoptotic Signaling Pathway Cartilage Development Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter Skin Development Negative Regulation Of Granulocyte Differentiation Myeloid Progenitor Cell Differentiation Positive Regulation Of Granulocyte Differentiation Connective Tissue Development Epidermis Development Protein Neddylation Organ Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone H4-R3 Methylation Osteoblast Fate Commitment Regulation Of Female Gonad Development Regulation Of Cellular Process Epithelium Development Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Response To Redox State Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Hematopoietic Stem Cell Proliferation Apoptotic Signaling Pathway Regulation Of Odontogenesis Of Dentin-containing Tooth System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Interferon-gamma Production Histone Arginine Methylation Regulation Of RNA Biosynthetic Process
Tagcloud ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx2 syndromes unmethylated	abl alfa aml1 amplified apl bcr characterizing clonospecific cml confirmation debate eto igh immunoglobin inv issues leukaemia mow myh1 offers opportunity presently progress purposes quantitate rearrangements residual tcr truly
Tagcloud (Difference) ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx2 syndromes unmethylated	abl alfa aml1 amplified apl bcr characterizing clonospecific cml confirmation debate eto igh immunoglobin issues mow myh1 offers opportunity presently progress purposes quantitate rearrangements residual tcr truly
Tagcloud (Intersection) ?		inv leukaemia