RUNX3 and DTX2

Number of citations of the paper that reports this interaction (PubMedID 37500075)
0

Data Source:
BioGRID (pull down, affinity chromatography technology)

		RUNX3	DTX2
Description		RUNX family transcription factor 3	deltex E3 ubiquitin ligase 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Core-binding Factor Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding ATP Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Chondrocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hemopoiesis Neuron Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Peripheral Nervous System Neuron Development Negative Regulation Of Epithelial Cell Proliferation Response To Transforming Growth Factor Beta	Notch Signaling Pathway Protein Ubiquitination
Pathways		Binding of TCF/LEF:CTNNB1 to target gene promoters RUNX3 regulates CDKN1A transcription RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates WNT signaling RUNX3 regulates YAP1-mediated transcription RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF RUNX3 regulates BCL2L11 (BIM) transcription Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Ankylosing spondylitis ( 21743469 23749187) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 32296059 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Celiac disease ( 20190752 22057235) Crohn's disease ( 23266558) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) IgA levels ( 28628107) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lead levels ( 26025379) Lymphocyte count ( 32888494) Male-pattern baldness ( 29146897 28196072 27182965) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) ( 24503447) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Type 1 diabetes ( 34012112)
Interacting Genes		18 interacting genes: CBFB DTX2 EP300 GLI1 GUCD1 HDAC1 HDAC2 HDAC4 HDAC5 MYCN NOTCH1 SMAD3 SMURF1 SMURF2 SP110 TLE1 TP53 YAP1	135 interacting genes: ABHD11 ABHD16A ACTMAP ALKBH4 ANAPC11 ANTKMT ARID5A ARMC7 ARNT2 BCL2L11 BICRAL BOLA2-SMG1P6 C10orf55 C1orf94 C22orf39 CCDC57 CFAP68 CIMIP1 CLPP COA6 COQ8A DAZAP2 DOK3 DTX1 DTX3 ECM1 ECSIT EIF4ENIF1 EIF4G1 EYA2 FAM168A FCRL4 FHL2 FHL5 FOXI1 FTO GLYCTK GOLGA2 H3C1 HDC HGS HLX HOXA1 HOXB2 HOXD12 HPCA HPCAL1 HPCAL4 HSFY1 HSFY2 IKZF3 KANK2 KLC3 KLHDC7B KRTAP11-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP26-1 KRTAP6-1 KRTAP7-1 KRTAP8-1 LASP1 LNX1 LRP2BP MBD3L1 MDC1 MED19 MSS51 MVP MXRA8 NCALD NCS1 NHLRC4 NIF3L1 NME4 NOTCH1 OIP5 PARP1 PARP10 PAX5 PLEKHF2 PLEKHG4 PLSCR1 POGZ PRR32 PRR34 PSMB4 QARS1 RBM11 RBPMS RFX6 RHOXF2 RIMBP3 RUNX1 RUNX2 RUNX3 RUSC1 SAXO4 SEC22A SEC23A SEC23B SEPSECS SLC67A1-AS SOHLH1 SPAG8 STX12 SUMO1 TBX15 TEKT5 TENT2 TMEM42 TRIB3 TRIM35 TRIM54 TRIP13 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBQLN4 USP54 VGLL3 VSNL1 ZNF34 ZNF503 ZNF620 ZNF641 ZNF764 ZNF774 ZNF85
Entrez ID		864	113878
HPRD ID		02565	16841
Ensembl ID		ENSG00000020633	ENSG00000091073
Uniprot IDs		Q13761	Q86UW9
PDB IDs		5W69	6IR0 6Y22 6Y2X 6Y3J
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Binding Nucleoplasm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Differentiation Chromatin Binding Protein Lysine Deacetylase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Negative Regulation Of RNA Metabolic Process Regulation Of Canonical Wnt Signaling Pathway Transcription Cis-regulatory Region Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Differentiation Negative Regulation Of Developmental Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Epidermal Cell Differentiation Regulation Of Multicellular Organismal Development Regulation Of Gliogenesis Positive Regulation Of RNA Metabolic Process Regulation Of Neurogenesis Negative Regulation Of Biosynthetic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Development Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Cell Differentiation Regulation Of Myotube Differentiation Transcription Regulator Complex	Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Axonemal A Tubule Inner Sheath Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Ubiquitin Conjugating Enzyme Activity Nucleus Core-binding Factor Complex Apoptotic Process Involved In Embryonic Digit Morphogenesis Chromatin Regulation Of Base-excision Repair Broad Specificity Oxidative DNA Demethylase Activity
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