RUNX3 and SP110

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		RUNX3	SP110
Gene Name		runt-related transcription factor 3	SP110 nuclear body protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleolus Cytoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle	Nucleus Nucleolus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding ATP Binding	DNA Binding Chromatin Binding Signal Transducer Activity Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chondrocyte Differentiation Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Protein Phosphorylation Axon Guidance Hair Follicle Morphogenesis Interferon-gamma Production Negative Regulation Of Cell Cycle Cell Maturation Peripheral Nervous System Neuron Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Signal Transduction Viral Process
Pathways
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 21743469) Celiac disease ( 20190752) Crohn's disease ( 23266558)	Chronic lymphocytic leukemia ( 18758461) Obesity-related traits ( 23251661)
Protein-Protein Interactions		13 interactors: CBFB EP300 HDAC1 HDAC2 HDAC4 HDAC5 NOTCH1 SMAD3 SMURF1 SMURF2 SP110 TLE1 YAP1	11 interactors: ANXA7 CDKN1A NAP1L2 NDUFV2 OSGEP RUNX3 SMN1 TK1 TSC22D1 TTR ZSCAN9
Entrez ID		864	3431
HPRD ID		02565	06832
Ensembl ID		ENSG00000020633	ENSG00000135899
Uniprot IDs		Q13761	G5E9C0 Q9HB58
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Histone H4 Deacetylation Regulation Of Transcription, DNA-templated Negative Regulation Of Ossification Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Gene Expression Histone H3 Deacetylation Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Histone H3-K9 Modification Regulation Of Striated Muscle Tissue Development Negative Regulation Of Osteoblast Differentiation Regulation Of Wnt Signaling Pathway Negative Regulation Of Cellular Metabolic Process Notch Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Signal Transduction Histone Deacetylation Transcription Initiation From RNA Polymerase II Promoter Protein Deacetylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Myotube Differentiation Chromatin Remodeling Negative Regulation Of Signaling Regulation Of Ossification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression, Epigenetic Regulation Of Canonical Wnt Signaling Pathway Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter	Nucleoside Metabolic Process Fetal Process Involved In Parturition Positive Regulation Of Histone H3-K14 Acetylation Threonylcarbamoyladenosine Biosynthetic Process Skeletal Muscle Cell Proliferation Cellular Metabolic Process Regulation Of Histone H3-K14 Acetylation Nucleobase-containing Compound Metabolic Process Digestive Tract Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Maturation Digestive System Development Positive Regulation Of Programmed Cell Death Threonylcarbamoyladenosine Metabolic Process Thyroid Hormone Transport Intestinal Epithelial Cell Maturation Anatomical Structure Development Response To Glucocorticoid Positive Regulation Of Cell Death Response To Corticosteroid Cellular Nitrogen Compound Metabolic Process Response To Cortisol Thymidine Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Response To Toxic Substance Regulation Of Stem Cell Division Positive Regulation Of Histone H3-K9 Acetylation Cellular Response To UV-B Deoxyribonucleoside Monophosphate Biosynthetic Process Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Developmental Process Nitrogen Compound Metabolic Process
Tagcloud ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx2 syndromes unmethylated	cavitary cc classification ct dimensionality employed except explore fresh gc genotype heterozygous homozygous instead mtb multifactor mybbp1a mycobacterium pathological progress promising ptb rela rs3809849 rs9061 rs9905742 tree tuberculosis whole
Tagcloud (Difference) ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx1 runx2 syndromes unmethylated	cavitary cc classification ct dimensionality employed except explore fresh gc genotype heterozygous homozygous instead mtb multifactor mybbp1a mycobacterium pathological progress promising ptb rela rs3809849 rs9061 rs9905742 tree tuberculosis whole
Tagcloud (Intersection) ?