CDK13 and SRSF1

Number of citations: 64 (PubMedID 18480452)
Data Source: BioGRID (enzymatic study)

		CDK13	SRSF1
Name		cyclin dependent kinase 13	serine and arginine rich splicing factor 1
Structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin K-CDK13 Complex Extracellular Region Extracellular Space Nucleus Nucleoplasm Golgi Apparatus Cytosol Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Speck Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Ficolin-1-rich Granule Lumen	Nucleus Nuclear Envelope Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Transferase Activity Protein Kinase Binding Cyclin Binding Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Protein Kinase B Binding DNA Topoisomerase Binding RS Domain Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of Signal Transduction Hemopoiesis Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Negative Regulation Of Stem Cell Differentiation	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Splice Site Recognition MRNA Processing RNA Splicing Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of RNA Splicing Protein Localization To Nucleus Regulation Of RNA Splicing MRNA Stabilization Oligodendrocyte Differentiation MRNA Transport Cardiac Muscle Contraction Cellular Response To Interleukin-17 Interleukin-17-mediated Signaling Pathway Liver Regeneration Protein Localization To P-body
Pathways		TP53 Regulates Transcription of DNA Repair Genes Neutrophil degranulation	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs		None	Copper
GWAS		Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Neutrophil percentage of white cells ( 32888494 ) Plateletcrit ( 32888494 ) Serum uric acid levels in response to allopurinol in gout ( 25676789 )	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 )
Interacting Genes		9 interacting genes: C1QBP CEBPA CHMP4A KRT31 PRPF40A RNF10 SRPK2 SRSF1 TRIM7	53 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDC42 CDK12 CDK13 CDK6 CDR1 CLK1 CLK2 CLK3 CLK4 CPSF7 DANCR DIDO1 DYRK1A FOXP1 GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L LUC7L3 NFYA NXF1 PPARG PRKN PRMT1 PRP4K PRPF4 PSIP1 RNF10 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2
Entrez ID		8621	6426
HPRD ID		04496	02887
Ensembl ID		ENSG00000065883	ENSG00000136450
Uniprot IDs		Q14004 Q9BVE2	Q07955 Q59FA2
PDB IDs		5EFQ 7NXJ	1X4A 2M7S 2M8D 2O3D 3BEG 4C0O 6HPJ 7ABG 8QO9
GO Terms Enriched among Interactors		RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Processing Regulation Of RNA Splicing MRNA Metabolic Process Macromolecule Metabolic Process RNA Metabolic Process Animal Organ Regeneration Organelle Organization Adrenergic Receptor Binding Regulation Of MRNA Metabolic Process RNA Processing RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Kininogen Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Vitamin B2 C/EBP Complex Protein Localization To P-body Nucleus Organization Nuclear Speck Negative Regulation Of MRNA Metabolic Process Liver Development C5-methylcytidine-containing RNA Reader Activity Deoxyribonuclease Inhibitor Activity Negative Regulation Of MDA-5 Signaling Pathway Nucleic Acid Metabolic Process CHOP-C/EBP Complex Nuclear Matrix Regeneration White Fat Cell Proliferation Regulation Of Cell Cycle DNA Topoisomerase Binding Nuclear Speck Organization Nucleus Cytosolic Ribosome Assembly Positive Regulation Of Gene Expression Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Mitochondrial Ribosome Binding Positive Regulation Of Trophoblast Cell Migration RS Domain Binding	MRNA Metabolic Process RNA Splicing MRNA Processing Nuclear Speck RNA Metabolic Process RNA Processing Nucleic Acid Metabolic Process Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Nucleus Protein-RNA Complex Assembly RNA Binding RNA Splicing, Via Transesterification Reactions Nucleoplasm Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of MRNA Processing Protein Serine/threonine Kinase Activity MRNA Splicing, Via Spliceosome Protein Serine Kinase Activity MRNA Splice Site Recognition Nucleic Acid Binding Protein-containing Complex Assembly Regulation Of MRNA Metabolic Process Spliceosomal Complex MRNA Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Protein-containing Complex Organization Negative Regulation Of RNA Splicing Protein Serine/threonine/tyrosine Kinase Activity Protein Kinase Activity Regulation Of RNA Metabolic Process Regulation Of Gene Expression U2-type Prespliceosome Regulation Of Macromolecule Biosynthetic Process Kinase Activity Regulation Of Primary Metabolic Process Positive Regulation Of Gene Expression Pre-mRNA 3'-splice Site Binding RS Domain Binding U2AF Complex Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Protein Tyrosine Kinase Activity Identical Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity