STK16 and PTH1R

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STK16	PTH1R
Description		serine/threonine kinase 16	parathyroid hormone 1 receptor
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Golgi-associated Vesicle Cytosol Plasma Membrane Membrane Nuclear Body Perinuclear Region Of Cytoplasm	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Receptor Complex
	Molecular Function	Nucleotide Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus	Skeletal System Development Ossification In Utero Embryonic Development Chondrocyte Differentiation Osteoblast Development Intracellular Calcium Ion Homeostasis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Bone Mineralization Bone Resorption Cell Maturation Positive Regulation Of Inositol Phosphate Biosynthetic Process
Pathways			Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs		Fostamatinib	Abaloparatide Parathyroid hormone Teriparatide
Diseases			Eiken dysplasia Blomstrand syndrome; Blomstrand chondrodysplasia Primary failure of tooth eruption Metaphyseal dysplasias, including: Metaphyseal dysplasia, Schmid type; Metaphyseal dysplasia, McKusik type; Metaphyseal dysplasia, Jansen type; Shwachman-Bodian-Diamond syndrome (SBDS); Metaphyseal anadysplasia (MAD)
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	Birth weight ( 27680694 31043758) Hip circumference adjusted for BMI ( 34021172) Microalbuminuria ( 26631737) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 2 diabetes ( 30054458) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		84 interacting genes: ADAMTSL4 AGR2 ARNT2 ATP23 BHLHA9 CALCOCO2 CBX3 CCDC33 CFP CRX CSKMT CSNK2B CYSRT1 DDIT4L DNAJA3 DRG1 EFEMP2 EFHC2 ELK1 FLACC1 FRS3 FXR1 GABPA IKZF3 INCA1 KCTD14 KCTD17 KLHL20 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP13-1 KRTAP13-2 KRTAP26-1 KRTAP6-3 MBP MEOX2 MGAT5B MIER3 MIIP MTUS2 NAA80 NAGK NBPF19 NIF3L1 NOTCH2NLA PCSK5 PKNOX2 PLA2G10 PLSCR1 PLSCR3 PRDM6 PRKAR1B PTH1R REL RFX6 RPIA RSPO4 SAXO1 SKIL SOCS2 SPRY2 SSC4D TCF12 TCF4 TLE5 TNFAIP1 TRAF3IP2 TRIM27 TRIM42 TRIP6 USP54 YPEL3 ZMAT1 ZNF330 ZNF343 ZNF774	16 interacting genes: ARRB1 GNB1 GPANK1 GUCD1 HOXA1 MGAT5B MKRN3 NHERF1 NHERF2 PTH PTHLH SMARCC1 STK16 TEKT4 UBC YWHAH
Entrez ID		8576	5745
HPRD ID		05281	01347
Ensembl ID		ENSG00000115661	ENSG00000160801
Uniprot IDs		B4DPS1 B8ZZI5 O75716	Q03431 Q0VGD7
PDB IDs		2BUJ	1BL1 3C4M 3H3G 3L2J 4Z8J 5EMB 6NBF 6NBH 6NBI 7UZO 7UZP 7VVJ 7VVK 7VVL 7VVM 7VVN 7VVO 7Y35 7Y36 8BIA 8BJ0 8D51 8D52 8FLQ 8FLR 8FLS 8FLT 8FLU 8GW8 8HA0 8HAF 8HAO 8JR9 9JR2 9JR3
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Lead Ion Binding Response To Peptide Response To Cytokine Identical Protein Binding Mercury Ion Binding PML Body	Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Peptide Hormone Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Insulin-like Growth Factor Receptor Binding Phosphate Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Negative Regulation Of Chondrocyte Differentiation CAMP Metabolic Process Negative Regulation Of Cartilage Development Protein-membrane Adaptor Activity Sensory Perception Molecular Adaptor Activity Semicircular Canal Formation Cyclic Purine Nucleotide Metabolic Process Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Glucocorticoid Catabolic Process Renal Phosphate Ion Absorption Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Activity Regulation Of Chondrocyte Differentiation Phosphatase Binding Bone Mineralization Angiotensin Receptor Binding Abducens Nerve Formation Optokinetic Behavior Regulation Of Sodium Ion Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding
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