SATB1 and CBS

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SATB1	CBS
Description		SATB homeobox 1	cystathionine beta-synthase
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Matrix Nuclear Body PML Body Nuclear Lumen	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Catalytic Activity Cystathionine Beta-synthase Activity Protein Binding Lyase Activity Oxygen Binding Enzyme Binding Heme Binding Pyridoxal Phosphate Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Nitrite Reductase (NO-forming) Activity Carbon Monoxide Binding Nitric Oxide Binding Modified Amino Acid Binding S-adenosyl-L-methionine Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II	Endochondral Ossification Blood Vessel Remodeling Cysteine Metabolic Process Cysteine Biosynthetic Process From Serine L-serine Metabolic Process L-serine Catabolic Process Superoxide Metabolic Process Amino Acid Biosynthetic Process Serine Family Amino Acid Metabolic Process Regulation Of Nitric Oxide Mediated Signal Transduction Cysteine Biosynthetic Process Via Cystathionine Cysteine Biosynthetic Process Transsulfuration L-cysteine Catabolic Process Cerebellum Morphogenesis Response To Nutrient Levels DNA Protection Negative Regulation Of Apoptotic Process Homocysteine Catabolic Process Sulfur Compound Biosynthetic Process Regulation Of JNK Cascade Homocysteine Metabolic Process Response To Folic Acid Maternal Process Involved In Female Pregnancy Cartilage Development Involved In Endochondral Bone Morphogenesis Hydrogen Sulfide Biosynthetic Process Cellular Response To Hypoxia Blood Vessel Diameter Maintenance
Pathways		Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins	Cysteine formation from homocysteine Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs			Pyridoxal phosphate Ademetionine Serine Cysteine
Diseases			Homocystinuria
GWAS		Adventurousness ( 30643258) Aspartate aminotransferase levels ( 33547301) Chronic mucus hypersecretion ( 24714607) Familial lung adenocarcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Itch intensity from mosquito bite ( 28199695) Left-handedness ( 32989287) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 22139419) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Sjögren's syndrome ( 24097067)	Blood and toenail selenium levels ( 25343990) Blood trace element (Se levels) ( 23720494) Homocysteine levels ( 20031578 23824729) Neutrophil count ( 32888494) Obesity-related traits ( 23251661) Plasma homocysteine levels (post-methionine load test) ( 24651765) Pre-treatment viral load in HIV-1 infection ( 31219150) Serum metabolite levels ( 33031748)
Interacting Genes		28 interacting genes: BAZ1A CASP6 CBS CBX4 CHD3 CUX1 EP300 FOXP1 FOXP2 FOXP4 GATA3 HDAC1 KAT2B MEOX2 MTA2 PIAS1 PIAS3 PIAS4 POLR2J SIRT1 SMARCA5 SPG21 SUMO1 SUMO1P1 TOPORS UBE2I UBR5 USP16	35 interacting genes: ATRX CBX4 CERT1 DAXX EHHADH FAF1 FXR1 FXR2 HGS HID1 HIPK1 HTT NTAQ1 PAX6 PIAS1 PIAS2 PIAS3 PIN1 PRKAG1 PRKAR1A PSMA1 RANBP9 SATB1 SLF2 SMARCAD1 SNCA SNRNP70 UBASH3A UBE2I UGP2 VTA1 ZDHHC17 ZMYM5 ZNF181 ZNF451
Entrez ID		6304	875
HPRD ID		03647	01994
Ensembl ID		ENSG00000182568	ENSG00000160200
Uniprot IDs		Q01826	B7Z2D6 P35520
PDB IDs		1YSE 2L1P 2MW8 2O49 2O4A 3NZL 3TUO 6LFF	1JBQ 1M54 4COO 4L0D 4L27 4L28 4L3V 4PCU 4UUU 5MMS 7QGT 8S5H 8S5I 8S5J 8S5K 8S5L 8S5M 8STW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of DNA-templated Transcription Chromatin Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II PML Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Chromatin Organization Post-translational Protein Modification Chromatin Remodeling SUMO Ligase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Transcription Coregulator Activity Protein Modification By Small Protein Conjugation Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Androgen Receptor Signaling Pathway DNA Damage Response DNA-binding Transcription Factor Binding Cellular Response To Stress Zinc Ion Binding Positive Regulation Of Metabolic Process Regulation Of Cell Fate Commitment Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Corepressor Activity Peptidyl-lysine Acetylation Positive Regulation Of Protein Sumoylation Metal Ion Binding NuRD Complex	PML Body Protein Sumoylation SUMO Ligase Activity SUMO Transferase Activity Postsynaptic Cytosol Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Speck Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of RNA Metabolic Process Enzyme Binding Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Protein Modification Process Transcription Corepressor Activity Phosphoprotein Binding Regulation Of Macromolecule Biosynthetic Process Protein Metabolic Process Macromolecule Metabolic Process CAMP-dependent Protein Kinase Regulator Activity Nuclear Body Protein Domain Specific Binding Regulation Of Protein Catabolic Process Negative Regulation Of Transcription By RNA Polymerase II Iris Morphogenesis Regulation Of Chaperone-mediated Autophagy Glutamatergic Synapse Cytosol Regulation Of Protein Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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