SATB1 and STT3B

		SATB1	STT3B
Description		SATB homeobox 1	STT3 oligosaccharyltransferase complex catalytic subunit B
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Matrix Nuclear Body PML Body Nuclear Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Oligosaccharyltransferase Complex Membrane Protein-containing Complex Oligosaccharyltransferase Complex B
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Oligosaccharyl Transferase Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II	Protein Glycosylation Protein N-linked Glycosylation Glycoprotein Catabolic Process Response To Unfolded Protein Protein N-linked Glycosylation Via Asparagine ERAD Pathway Post-translational Protein Modification
Pathways		Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins	Asparagine N-linked glycosylation Maturation of spike protein Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Aspartate aminotransferase levels ( 33547301) Chronic mucus hypersecretion ( 24714607) Familial lung adenocarcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Itch intensity from mosquito bite ( 28199695) Left-handedness ( 32989287) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 22139419) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Sjögren's syndrome ( 24097067)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Diabetic retinopathy in type 2 diabetes ( 33607655) Periodontal disease-related phenotype (Socransky) ( 24347629) Urate levels ( 31578528)
Interacting Genes		28 interacting genes: BAZ1A CASP6 CBS CBX4 CHD3 CUX1 EP300 FOXP1 FOXP2 FOXP4 GATA3 HDAC1 KAT2B MEOX2 MTA2 PIAS1 PIAS3 PIAS4 POLR2J SIRT1 SMARCA5 SPG21 SUMO1 SUMO1P1 TOPORS UBE2I UBR5 USP16	2 interacting genes: FILNC1 INCA1
Entrez ID		6304	201595
HPRD ID		03647	12268
Ensembl ID		ENSG00000182568	ENSG00000163527
Uniprot IDs		Q01826	Q8TCJ2
PDB IDs		1YSE 2L1P 2MW8 2O49 2O4A 3NZL 3TUO 6LFF	6S7T
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Negative Regulation Of DNA-templated Transcription Chromatin Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II PML Body Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Chromatin Organization Post-translational Protein Modification Chromatin Remodeling SUMO Ligase Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Transcription Coregulator Activity Protein Modification By Small Protein Conjugation Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Androgen Receptor Signaling Pathway DNA Damage Response DNA-binding Transcription Factor Binding Cellular Response To Stress Zinc Ion Binding Positive Regulation Of Metabolic Process Regulation Of Cell Fate Commitment Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Corepressor Activity Peptidyl-lysine Acetylation Positive Regulation Of Protein Sumoylation Metal Ion Binding NuRD Complex	Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Sterol 14-demethylase Activity Cholesterol Biosynthetic Process Via 24,25-dihydrolanosterol Xylulose Catabolic Process D-xylulokinase Activity Aspartate Family Amino Acid Metabolic Process Glycine N-methyltransferase Activity Methionine-glyoxylate Transaminase Activity Glycine:2-oxoglutarate Aminotransferase Activity 2-aminoadipate Transaminase Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Hepatic Stellate Cell Proliferation Protein Tyrosine Kinase Collagen Receptor Activity RNA Strand-exchange Activity Eukaryotic Translation Initiation Factor 4F Complex Assembly Xylulose Metabolic Process Sarcosine Metabolic Process S-adenosylhomocysteine Metabolic Process Kynurenine-glyoxylate Transaminase Activity GET Complex Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Phosphorylation Regulation Of Fibroblast Proliferation D-xylose Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine
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