BLZF1 and HCLS1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		BLZF1	HCLS1
Description		basic leucine zipper nuclear factor 1	hematopoietic cell-specific Lyn substrate 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cis-Golgi Network Membrane	Nucleus Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Endocytic Vesicle
	Molecular Function	Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding	Protein Binding SH3 Domain Binding Protein Kinase Binding Signaling Adaptor Activity Protein-containing Complex Binding Actin Filament Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Golgi Organization Protein Transport Vesicle-mediated Transport Golgi To Plasma Membrane Protein Transport	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Hormone Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Intracellular Signal Transduction Granulocyte Colony-stimulating Factor Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Nuclear Transport Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Cytokine Stimulus Negative Regulation Of Leukocyte Apoptotic Process
Pathways		Golgi Cisternae Pericentriolar Stack Reorganization
Drugs
Diseases
GWAS
Interacting Genes		100 interacting genes: AKAP9 AMOTL2 ANKS1A AQP1 BAG4 BANP BCL6 BEX2 CARD9 CCDC120 CCDC33 CCNH CDC37 CDK18 CFAP206 CHCHD3 CINP CKS2 DNMT3L ENKD1 ERCC3 EWSR1 EXOC8 FAM124B FAM90A1 FBF1 FHL2 FRMD6 FRS3 GEM GORASP2 HCLS1 HDAC4 HOXA1 HOXC8 IGFN1 IKZF3 IL16 IQUB KANK2 KAT5 KCTD9 KDM1A KIF9 KLHL38 LGALS14 LMO1 LMO2 LMO3 LNX1 MID2 MISP MKRN3 NTAQ1 OAZ3 PCDHB12 PIK3R3 PKN1 POLR1C PRKAB2 PRMT6 PRPF18 PSMA1 PTPN11 RAB2A RAB2B RAB39A RANBP3 RHOJ SCNM1 SMAD3 SMARCB1 SPRED1 SRA1 SSX2 SUV39H2 SYT17 TBC1D22B TBC1D7 TCAP TCF19 TEKT4 TNS2 TRAPPC2L TRIM59 TSC22D4 TSTD2 TTC23 TXNDC5 USHBP1 VPS28 ZBTB16 ZBTB24 ZGPAT ZMAT1 ZNF124 ZNF410 ZNF688 ZNF76 ZZZ3	25 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CRYAA CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SH3BP2 SSBP3 SYK TERF1 TRIM29 WAS ZBTB25
Entrez ID		8548	3059
HPRD ID		16367	03199
Ensembl ID		ENSG00000117475	ENSG00000180353
Uniprot IDs		Q9H2G9	E7EVW7 P14317
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Transcription Coactivator Activity Regulation Of RNA Metabolic Process Zinc Ion Binding Negative Regulation Of Transcription By RNA Polymerase II	B Cell Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding SH3 Domain Binding Actin Cytoskeleton Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Meiotic Chromosome Movement Towards Spindle Pole B Cell Homeostasis Immune Response-activating Signaling Pathway Regulation Of Mast Cell Degranulation B Cell Receptor Complex Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Metabolic Process Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Lamellipodium Assembly Positive Regulation Of Macromolecule Metabolic Process Activation Of Immune Response Actin Filament Organization Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Macromolecule Biosynthetic Process Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Meiotic Cytokinesis Fc Receptor Signaling Pathway Arp2/3 Protein Complex Negative Regulation Of Immune System Process Lymphocyte Homeostasis Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Type II Interferon Asymmetric Cell Division Regulation Of Autophagy Leukocyte Homeostasis Immune Response Positive Regulation Of Mast Cell Degranulation Chromosome Localization Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Immune Response Innate Immune Response Negative Regulation Of B Cell Proliferation Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Immune Response Regulation Of Immune Response Regulation Of Cellular Component Organization
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