ARR3 and PTAFR

Number of citations of the paper that reports this interaction (PubMedID 11729201)
0

Data Source:
HPRD (in vivo, in vitro)

		ARR3	PTAFR
Description		arrestin 3	platelet activating factor receptor
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cell Projection Synapse	Plasma Membrane Membrane Secretory Granule Membrane Tertiary Granule Membrane
	Molecular Function	G Protein-coupled Receptor Binding Opsin Binding Protein Binding Phosphoprotein Binding	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity G Protein-coupled Receptor Activity Platelet Activating Factor Receptor Activity Protein Binding Phospholipid Binding G Protein-coupled Purinergic Nucleotide Receptor Activity
	Biological Process	G Protein-coupled Receptor Internalization Endocytosis Signal Transduction Visual Perception	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway
Pathways			Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events Interleukin-10 signaling Neutrophil degranulation Interferon gamma signaling
Drugs			Platelet Activating Factor Etizolam Rupatadine
Diseases
GWAS			Blond vs. brown/black hair color ( 30531825)
Interacting Genes		20 interacting genes: ADRB2 AP3B1 CAPNS1 CLTC CSNK2A1 DVL2 FSHR GNMT MAP2K7 MARCHF8 OPN1MW OPN4 PLK4 PTAFR RCOR2 RHO RNASE6 SRC ZBTB43 ZNF496	19 interacting genes: ARR3 ARRB2 CALM1 GORAB GRIN1 GTPBP3 IFITM3 MBP PLLP PPM1J PRNP RGS4 RHBDD2 SERINC5 SLC33A2 SPATA24 TMEM120A TMX2 TYK2
Entrez ID		407	5724
HPRD ID		02358	01422
Ensembl ID		ENSG00000120500	ENSG00000169403
Uniprot IDs		P36575	A8K7N8 P25105
PDB IDs			5ZKP 5ZKQ 8XYD
Enriched GO Terms of Interacting Partners?		Photoreceptor Activity G Protein-coupled Photoreceptor Activity Thermotaxis Photoreceptor Disc Membrane G Protein-coupled Receptor Activity Detection Of Visible Light Sperm Head Plasma Membrane Absorption Of Visible Light Phototransduction Detection Of Temperature Stimulus Involved In Thermoception 11-cis Retinal Binding G Protein-coupled Receptor Signaling Pathway Response To Temperature Stimulus Detection Of Light Stimulus Positive Regulation Of MAPK Cascade Lysosome Transcytosis Regulation Of Organelle Organization Cellular Response To Light Stimulus Detection Of Temperature Stimulus Involved In Sensory Perception Uterus Development Clathrin-coated Endocytic Vesicle Detection Of Temperature Stimulus Bone Resorption Detection Of Abiotic Stimulus Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Light Stimulus Enzyme Binding Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Vacuolar Transport Regulation Of Systemic Arterial Blood Pressure Regulation Of MAPK Cascade Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Bone Remodeling Regulation Of Bone Resorption Follicle-stimulating Hormone Receptor Activity Regulation Of Acetylcholine Metabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Radiation Rod Bipolar Cell Differentiation RNA Polymerase III General Transcription Initiation Factor Binding Glycine N-methyltransferase Activity Positive Regulation Of ERK1 And ERK2 Cascade Visual Perception Sensory Perception Of Light Stimulus Regulation Of Macroautophagy Response To Radiation Protein Targeting To Vacuole Vasodilation Fc Receptor Signaling Pathway	Myelin Sheath Compact Myelin G Protein-coupled Receptor Internalization Modulation Of Chemical Synaptic Transmission Regulation Of Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Structural Constituent Of Myelin Sheath Myelination Axon Ensheathment Regulation Of Monoatomic Ion Transmembrane Transport Protein Heterooligomerization Positive Regulation Of Synaptic Transmission Regulation Of Calcium Ion Transmembrane Transport Regulation Of Metal Ion Transport Positive Regulation Of Excitatory Postsynaptic Potential Response To Interferon-beta Positive Regulation Of Signal Transduction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Substantia Nigra Development Regulation Of Monoatomic Ion Transport Terminal Bouton Propylene Metabolic Process Positive Regulation Of Metalloendopeptidase Activity Type 8 Metabotropic Glutamate Receptor Binding Response To Virus Regulation Of Membrane Potential Positive Regulation Of Receptor Signaling Pathway Via STAT Calmodulin Binding Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity Cellular Response To Amyloid-beta Angiotensin Receptor Binding Positive Regulation Of Cell Communication Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Excitatory Postsynaptic Potential Intracellular Signal Transduction Positive Regulation Of Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Glycine Response To Amyloid-beta Negative Regulation Of Glycine Import Across Plasma Membrane Type I Interferon-mediated Signaling Pathway Regulation Of Transcytosis TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Nervous System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Potassium Ion Transmembrane Transport
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