AGPS and BLVRA

Data Source: HiPPIP (Novel)

		AGPS	BLVRA
Name		alkylglycerone phosphate synthase	biliverdin reductase A
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Catalytic Activity Protein Binding Alkylglycerone-phosphate Synthase Activity Transferase Activity Flavin Adenine Dinucleotide Binding FAD Binding	Nucleotide Binding Biliverdin Reductase [NAD(P)H] Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding Biliberdin Reductase (NADH) Activity Biliverdin Reductase (NADPH) Activity
	Biological Process	Lipid Metabolic Process Lipid Biosynthetic Process Ether Lipid Biosynthetic Process	Fatty Acid Metabolic Process Triglyceride Metabolic Process Chemotaxis Inflammatory Response Response To Oxidative Stress Gene Expression Response To Food Response To Lipopolysaccharide Lipid Oxidation Complement Component C5a Signaling Pathway Heme Catabolic Process Pigment Metabolic Process Sensory Perception Of Itch Response To Cyclosporin A
Pathways		Plasmalogen biosynthesis Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	Heme degradation Cytoprotection by HMOX1
Drugs		None	NADH
Diseases		Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	None
GWAS		Height ( 28552196 )	Mean corpuscular volume ( 32888494 ) Peak insulin response ( 28490609 )
Interacting Genes		2 interacting genes: GNPAT GORASP1	5 interacting genes: AKT1 AKT2 LNX1 PRKCB PRKCZ
Entrez ID		8540	644
HPRD ID		04337	11229
Ensembl ID		ENSG00000018510	ENSG00000106605
Uniprot IDs		B7Z3Q4 O00116	A0A140VJF4 P53004
PDB IDs		Not available	2H63
GO Terms Enriched among Interactors		None	Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Transferase Activity Regulation Of D-glucose Transmembrane Transport Protein Serine Kinase Activity Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Peripheral Nervous System Myelin Maintenance Cellular Response To Insulin Stimulus Protein Serine/threonine Kinase Activity Negative Regulation Of Transmembrane Transport Negative Regulation Of PERK-mediated Unfolded Protein Response Mammary Gland Epithelial Cell Differentiation Glycogen Biosynthetic Process Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Fatty Acid Beta-oxidation Myelin Maintenance Positive Regulation Of Glycogen Biosynthetic Process Protein Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Response To Insulin Cell Cortex Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Peptide Hormone Stimulus Kinase Activity Protein Localization To Plasma Membrane Polysaccharide Biosynthetic Process Protein Modification Process Protein Localization To Cell Periphery Regulation Of Glycogen Biosynthetic Process Regulation Of Fatty Acid Transport Regulation Of Fatty Acid Oxidation Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of D-glucose Import Negative Regulation Of Lipid Transport Regulation Of Glycogen Metabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Glucose Metabolic Process Response To Peptide Hormone Protein Localization To Membrane Positive Regulation Of Translational Initiation Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Hormone Stimulus Protein Phosphorylation Regulation Of D-glucose Import Regulation Of Lipid Catabolic Process Glycogen Metabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration