AGPS and NFIA

Data Source: HiPPIP (Novel)

		AGPS	NFIA
Name		alkylglycerone phosphate synthase	nuclear factor I A
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Peroxisome Peroxisomal Membrane Peroxisomal Matrix Cytosol Membrane	Chromatin Nucleus Nucleoplasm Cell Junction
	Molecular Function	Catalytic Activity Protein Binding Alkylglycerone-phosphate Synthase Activity Transferase Activity Flavin Adenine Dinucleotide Binding FAD Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Lipid Metabolic Process Lipid Biosynthetic Process Ether Lipid Biosynthetic Process	Cell Morphogenesis DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Wounding Exit From Mitosis Gene Expression Glial Cell Proliferation Viral Genome Replication Glial Cell Fate Specification Neurogenesis BMP Signaling Pathway Limb Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Specification Generation Of Neurons Cartilage Development Retina Development In Camera-type Eye Synapse Maturation Neural Precursor Cell Proliferation Ureter Development
Pathways		Plasmalogen biosynthesis Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Diseases		Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1); Rhizomelic chondrodysplasia punctata, type II (RCDP2); Rhizomelic chondrodysplasia punctata, type III (RCDP3)	None
GWAS		Height ( 28552196 )	Arthritis (oligoarticular juvenile idiopathic) ( 34101054 ) Autism ( 30675382 ) Bipolar disorder ( 21738484 ) Blond vs. brown/black hair color ( 30531825 ) Celiac disease ( 20190752 25920553 30572963 ) Cobalt levels ( 26025379 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic conduction measures ( 23463857 ) Electrocardiographic traits (multivariate) ( 32602732 ) Erectile dysfunction ( 30583798 ) Feeling nervous ( 29500382 ) General risk tolerance (MTAG) ( 30643258 ) Global electrical heterogeneity phenotypes ( 29622589 ) HDL cholesterol levels ( 32203549 ) Heel bone mineral density ( 30598549 ) Hip circumference adjusted for BMI ( 28552196 ) Homeostasis model assessment of insulin resistance ( 33381925 ) JT interval (sulfonylurea treatment interaction) ( 27958378 ) Myopia ( 27182965 ) Number of sexual partners ( 30643258 ) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681 ) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377 ) PR interval ( 32439900 ) QRS duration ( 27577874 27659466 30679814 ) QT interval (sulfonylurea treatment interaction) ( 27958378 ) Refractive error ( 32231278 ) Regular attendance at a religious group ( 29970889 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 ) Triglyceride levels ( 32203549 )
Novel Interactors		12 novel interactors: BLVRA BOLL CHRND CS FKBP7 GORASP2 KCNH7 KEL LST1 NFIA PDE11A TSFM	1 novel interactors: AGPS
Interacting Genes		2 interacting genes: GNPAT GORASP1	20 interacting genes: CREBBP ELK3 ERG ETV7 FBXO7 FOS FOXL1 GABARAPL1 GATA2 GATA3 KLF16 KLF8 LHX2 LHX3 NHLH1 PLEKHF2 SFN SMAD2 TBXT UBC
Entrez ID		8540	4774
HPRD ID		04337	09007
Ensembl ID		ENSG00000018510	ENSG00000162599
Uniprot IDs		B7Z3Q4 O00116	Q12857
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding DNA-binding Transcription Factor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Cellular Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Transcription Regulator Complex Neuroepithelial Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Transcription Coregulator Binding Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Thyroid-stimulating Hormone-secreting Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of MiRNA Transcription Mesoderm Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Developmental Process Positive Regulation Of Biosynthetic Process