ARHGAP19 and ATXN3

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ARHGAP19	ATXN3
Gene Name		Rho GTPase activating protein 19	ataxin 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrial Matrix Cytosol Nuclear Matrix Mitochondrial Membrane Nuclear Inclusion Body
	Molecular Function	GTPase Activator Activity	Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding ATPase Binding Lys63-specific Deubiquitinase Activity Lys48-specific Deubiquitinase Activity
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Microtubule Cytoskeleton Organization Nucleotide-excision Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Misfolded Or Incompletely Synthesized Protein Catabolic Process Synaptic Transmission Nervous System Development Regulation Of Cell-substrate Adhesion Actin Cytoskeleton Organization Cellular Response To Heat Monoubiquitinated Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intermediate Filament Cytoskeleton Organization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Misfolded Protein
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS			Height ( 18391950 18391951) Orofacial clefts ( 22419666)
Protein-Protein Interactions		1 interactors: ATXN3	43 interactors: ANXA7 APP ARHGAP19 ARHGDIA ASIC1 C16orf70 CASP1 CDKN1A CSNK2B DNM2 EWSR1 GSK3B HDAC6 KAT2B MKNK1 NCOR1 PARK2 PICK1 PJA1 PSMD7 RAD23A RAD23B RFFL RPS6KA1 SQSTM1 STUB1 SUMO1 TEX11 TK1 TRAF6 TRIM54 TRIM55 TRIM63 TUBA1A TUBB UBB UBC UBE2L3 UBE2S UBE4B UBQLN1 USP21 VCP
Entrez ID		84986	4287
HPRD ID		12475	06131
Ensembl ID		ENSG00000213390	ENSG00000066427
Uniprot IDs		Q14CB8	P54252
PDB IDs			1YZB 2AGA 2DOS 2JRI 2KLZ
Enriched GO Terms of Interacting Partners?		Monoubiquitinated Protein Deubiquitination Cellular Response To Misfolded Protein Misfolded Or Incompletely Synthesized Protein Catabolic Process Response To Misfolded Protein Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cellular Response To Heat Nucleotide-excision Repair Protein Deubiquitination Cellular Response To Topologically Incorrect Protein Response To Heat Protein Modification By Small Protein Removal Response To Temperature Stimulus Regulation Of Cell-substrate Adhesion	Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Proteolysis Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Macromolecule Catabolic Process Protein Ubiquitination Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Regulation Of Catalytic Activity Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Metabolic Process Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Abiotic Stimulus Cellular Response To Stress Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Cell Death Catabolic Process Response To Growth Factor Protein Metabolic Process Regulation Of Metabolic Process Apoptotic Process Programmed Cell Death Regulation Of Apoptotic Process Cell Death Death Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Catabolic Process
Tagcloud ?		124a 193a 193b a2780 brdu ccnd1 discover discovered erbb4 genomewide incorporation kras library mcl1 micrornas mimic mir mir193a mir193b mirna mirnas noncoding ovarian proliferative rnas screen screens suppressive utr	14q32 amplifies ataxia atm atnx3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless pnkp polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Difference) ?		124a 193a 193b a2780 brdu ccnd1 discover discovered erbb4 genomewide incorporation kras library mcl1 micrornas mimic mir mir193a mir193b mirna mirnas noncoding ovarian proliferative rnas screen screens suppressive utr	14q32 amplifies ataxia atm atnx3 break breaks cag deposited eventually expansions glutamine inactivated inefficient joseph machado mjd neurodegeneration nonetheless pnkp polymorphic polynucleotide polyq sca3 spinocerebellar strand telangiectasia tri untreatable
Tagcloud (Intersection) ?