AIFM2 and PLXNB2

Number of citations of the paper that reports this interaction (PubMedID 36423520)
50

Data Source:
BioGRID (unspecified method)

		AIFM2	PLXNB2
Description		AIF family member 2	plexin B2
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GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Mitochondrial Membrane	Semaphorin Receptor Complex Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	DNA Binding Electron-transferring-flavoprotein Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Flavin Adenine Dinucleotide Binding	Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Signaling Receptor Activity
	Biological Process	Ubiquinone Metabolic Process Apoptotic Mitochondrial Changes Respiratory Electron Transport Chain Vitamin K Metabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Ferroptosis Regulation Of Cellular Response To Oxidative Stress Cellular Detoxification	Neural Tube Closure Regulation Of Protein Phosphorylation Cytoplasmic Translation Receptor-mediated Endocytosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Neuroblast Proliferation Synapse Assembly Brain Development Regulation Of Cell Shape Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Regulation Of Cell Migration Positive Regulation Of Cell Projection Organization Negative Regulation Of Translation In Response To Stress Cellular Response To Stress TRNA Stabilization Regulation Of GTPase Activity Positive Regulation Of Translation Positive Regulation Of Axonogenesis Regulation Of Protein Metabolic Process Semaphorin-plexin Signaling Pathway Excitatory Synapse Assembly Regulation Of Neuron Migration
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Rheumatoid arthritis ( 30891314)	Acne (severe) ( 24927181) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sensorimotor dexterity ( 31596458) Systolic blood pressure ( 30224653)
Interacting Genes		3 interacting genes: CNPY4 PLXNB2 TRIM21	9 interacting genes: AIFM2 ARHGEF11 ARHGEF12 CENPU HDLBP HMOX2 PFDN1 PTN RND1
Entrez ID		84883	23654
HPRD ID		09797	05050
Ensembl ID		ENSG00000042286	ENSG00000196576
Uniprot IDs		Q9BRQ8	O15031
PDB IDs		8JSC 8WIK 8YO8 8YOQ 8YOX	4E71
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Deubiquitination Stress Granule Disassembly Positive Regulation Of Protein Binding Negative Regulation Of Protein Deubiquitination TRNA Stabilization Excitatory Synapse Assembly Negative Regulation Of Translation In Response To Stress Positive Regulation Of Viral Entry Into Host Cell Suppression Of Viral Release By Host Protein K27-linked Ubiquitination Negative Regulation Of Viral Transcription Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Viral Transcription Negative Regulation Of Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Translation In Response To Stress
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