AIFM2 and CNPY4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AIFM2	CNPY4
Description		AIF family member 2	canopy FGF signaling regulator 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lipid Droplet Cytosol Plasma Membrane Membrane Mitochondrial Membrane	Extracellular Region
	Molecular Function	DNA Binding Electron-transferring-flavoprotein Dehydrogenase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Flavin Adenine Dinucleotide Binding	Signaling Receptor Binding Protein Binding
	Biological Process	Ubiquinone Metabolic Process Apoptotic Mitochondrial Changes Respiratory Electron Transport Chain Vitamin K Metabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Ferroptosis Regulation Of Cellular Response To Oxidative Stress Cellular Detoxification	Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245) Rheumatoid arthritis ( 30891314)	Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Refractive error ( 32231278) Renal overload gout ( 32238385) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		3 interacting genes: CNPY4 PLXNB2 TRIM21	3 interacting genes: AIFM2 ARL4D TLR4
Entrez ID		84883	245812
HPRD ID		09797	14611
Ensembl ID		ENSG00000042286	ENSG00000166997
Uniprot IDs		Q9BRQ8	Q8N129
PDB IDs		8JSC 8WIK 8YO8 8YOQ 8YOX
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Deubiquitination Stress Granule Disassembly Positive Regulation Of Protein Binding Negative Regulation Of Protein Deubiquitination TRNA Stabilization Excitatory Synapse Assembly Negative Regulation Of Translation In Response To Stress Positive Regulation Of Viral Entry Into Host Cell Suppression Of Viral Release By Host Protein K27-linked Ubiquitination Negative Regulation Of Viral Transcription Semaphorin Receptor Activity Semaphorin Receptor Complex Regulation Of Viral Transcription Negative Regulation Of Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Translation In Response To Stress	Negative Regulation Of Interleukin-23 Production Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Detection Of Fungus Nitric Oxide Production Involved In Inflammatory Response Wound Healing Involved In Inflammatory Response MHC Class II Biosynthetic Process Electron-transferring-flavoprotein Dehydrogenase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Matrix Metallopeptidase Secretion MyD88-dependent Toll-like Receptor Signaling Pathway Negative Regulation Of Interleukin-17 Production Positive Regulation Of Apoptotic Process Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Matrix Metallopeptidase Secretion Regulation Of Interleukin-23 Production Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Cellular Response To Lipoteichoic Acid Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Programmed Cell Death Detection Of Molecule Of Bacterial Origin Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Platelet Activation Intestinal Epithelial Structure Maintenance Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Lipopolysaccharide Receptor Complex MyD88-independent Toll-like Receptor Signaling Pathway NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating Lipopolysaccharide Immune Receptor Activity Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Detection Of Lipopolysaccharide Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process NK T Cell Activation Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of Cellular Response To Stress B Cell Proliferation Involved In Immune Response Positive Regulation Of Stress-activated MAPK Cascade Astrocyte Development Microglia Differentiation T-helper 1 Type Immune Response Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Ubiquinone Metabolic Process Regulation Of Ferroptosis Vitamin K Metabolic Process Negative Regulation Of Ferroptosis Regulation Of Cellular Response To Oxidative Stress
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