PLEKHA8 and ARF1

Number of citations of the paper that reports this interaction (PMID 15107860)
137

Data Source:
HPRD (in vitro)

		PLEKHA8	ARF1
Gene Name		pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	ADP-ribosylation factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Trans-Golgi Network Membrane	Golgi Membrane Cytosol Plasma Membrane Focal Adhesion Postsynaptic Density Sarcomere Neuron Projection Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Glycolipid Transporter Activity Glycolipid Binding Phosphatidylinositol-4-phosphate Binding Ceramide Binding	GTPase Activity Receptor Signaling Protein Activity Protein Binding GTP Binding Poly(A) RNA Binding
	Biological Process	Lipid Transport Protein Transport ER To Golgi Ceramide Transport Glycolipid Transport	Regulation Of Receptor Internalization Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Cellular Copper Ion Homeostasis Retrograde Vesicle-mediated Transport, Golgi To ER Post-Golgi Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Protein Transport Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Arp2/3 Complex-mediated Actin Nucleation Small Molecule Metabolic Process COPI Coating Of Golgi Vesicle Regulation Of Defense Response To Virus By Virus Long Term Synaptic Depression Membrane Organization Dendritic Spine Organization
Pathways			Synthesis of PIPs at the Golgi membrane Metabolism of lipids and lipoproteins Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters HIV Infection Golgi Associated Vesicle Biogenesis Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Golgi to ER Retrograde Transport MHC class II antigen presentation COPI Mediated Transport Phospholipid metabolism trans-Golgi Network Vesicle Budding Nef Mediated CD4 Down-regulation Adaptive Immune System PI Metabolism
Drugs
Diseases
GWAS		Estradiol levels ( 22675492)
Protein-Protein Interactions		2 interactors: ARF1 CDKN2A	40 interactors: AP1B1 AP1G1 AP3B1 AP3D1 AP3S2 AP4E1 AP4M1 ARFGAP1 ARFIP1 ARFIP2 ARHGAP21 ASAP1 ASAP2 CHRM3 COPB1 COPE COPG1 CYTH1 CYTH2 EEF1G GGA1 GGA2 GGA3 GOSR2 INSR KDELR1 MDM4 NOA1 NPM1 PICK1 PIP5K1A PLD1 PLD2 PLEKHA8 PLIN2 RALA TMED10 TMED2 TMEM106A WBP11
Entrez ID		84725	375
HPRD ID		10555	00054
Ensembl ID		ENSG00000106086	ENSG00000143761
Uniprot IDs		Q96JA3	P84077
PDB IDs			1HUR 1RE0 1U81 3O47 4HMY
Enriched GO Terms of Interacting Partners?		Senescence-associated Heterochromatin Focus Assembly Positive Regulation Of Cellular Senescence Positive Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Macrophage Apoptotic Process Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Cell Aging Small GTPase Mediated Signal Transduction Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of T Cell Differentiation In Thymus Heterochromatin Assembly COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Positive Regulation Of Protein Sumoylation Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Smooth Muscle Cell Apoptotic Process Golgi Vesicle Budding Heterochromatin Organization Regulation Of Macrophage Apoptotic Process Replicative Senescence Positive Regulation Of Signal Transduction By P53 Class Mediator Long Term Synaptic Depression Negative Regulation Of B Cell Proliferation Cellular Copper Ion Homeostasis Regulation Of Protein Sumoylation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Copper Ion Homeostasis Regulation Of Actin Nucleation Protein Destabilization Regulation Of Execution Phase Of Apoptosis Regulation Of Cellular Senescence Regulation Of Defense Response To Virus By Virus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Somatic Stem Cell Division Cellular Senescence Vesicle Targeting, To, From Or Within Golgi Regulation Of Receptor Internalization Regulation Of Protein Export From Nucleus Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Leukocyte Apoptotic Process Protein K63-linked Ubiquitination Negative Regulation Of T Cell Differentiation Regulation Of Immune System Process Retrograde Vesicle-mediated Transport, Golgi To ER Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of B Cell Activation Regulation Of Myeloid Cell Apoptotic Process Localization Within Membrane	Intracellular Protein Transport Intracellular Transport Establishment Of Localization In Cell Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Cellular Localization Cellular Protein Localization Protein Localization COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Golgi Vesicle Budding Golgi Vesicle Transport Localization Within Membrane Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Transport Establishment Of Organelle Localization Vesicle Targeting, To, From Or Within Golgi Retrograde Vesicle-mediated Transport, Golgi To ER Organelle Localization Vesicle Targeting Membrane Organization Membrane Budding Organelle Organization Regulation Of ARF Protein Signal Transduction Cytoplasmic Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Anterograde Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Post-Golgi Vesicle-mediated Transport Anterograde Axon Cargo Transport ER To Golgi Vesicle-mediated Transport Regulation Of GTPase Activity Synaptic Vesicle Transport Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Positive Regulation Of NK T Cell Differentiation Establishment Of Golgi Localization Golgi To Vacuole Transport Regulation Of Ras Protein Signal Transduction Endosome To Melanosome Transport Cargo Loading Into Vesicle Pigment Granule Maturation Axon Cargo Transport Intra-Golgi Vesicle-mediated Transport Cellular Pigment Accumulation Cellular Pigmentation
Tagcloud ?			adp bulk close coated coatomer consumed contact copi dynamics endoplasmic exchange explored fission golgi governed gtpase interconnected maintain maintenance mitochondria mitochondrial powerhouse presumably produce proximity reticulum ribosylation thought vesicles
Tagcloud (Difference) ?			adp bulk close coated coatomer consumed contact copi dynamics endoplasmic exchange explored fission golgi governed gtpase interconnected maintain maintenance mitochondria mitochondrial powerhouse presumably produce proximity reticulum ribosylation thought vesicles
Tagcloud (Intersection) ?